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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: UGDH-AS1 (ImmuneEditome ID:100885776)

1. Gene summary of enriched editing regions for UGDH-AS1

check button Gene summary
Gene informationGene symbol

UGDH-AS1

Gene ID

100885776

GeneSynonyms-
GeneCytomap

4p14

GeneTypencRNA
GeneDescriptionUGDH antisense RNA 1 (non-protein coding)
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr4:39530805-39535574:+ENST00000504032.1ENSG00000249348.1UGDH-AS1ncRNA_exonicAluSx4,AluJb,AluSg7,THE1B-int,AluY,AluSx1,THE1Bchr4:39530805-39535574:+.alignment
chr4:39537084-39538448:+ENST00000504032.1ENSG00000249348.1UGDH-AS1ncRNA_intronicL2b,AluSg,AluJb,AluSz6chr4:39537084-39538448:+.alignment
chr4:39545262-39546162:+ENST00000504032.1ENSG00000249348.1UGDH-AS1ncRNA_intronicAluSg4,AluSc,AluJrchr4:39545262-39546162:+.alignment


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2. Tumor-specific enriched editing regions for UGDH-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr4:39530805-39535574:+KIRCEER4.7304e-02image
ENSG00000249348.1,UGDH-AS1KIRCEAG3.8105e-02image
chr4:39530805-39535574:+KIRPEER7.7060e-05image
ENSG00000249348.1,UGDH-AS1KIRPEAG9.6611e-05image
chr4:39530805-39535574:+LUSCEER5.2112e-03image
ENSG00000249348.1,UGDH-AS1LUSCEAG5.0578e-03image
chr4:39530805-39535574:+STADEER1.0662e-03image
ENSG00000249348.1,UGDH-AS1STADEAG7.9747e-04image
chr4:39530805-39535574:+THCAEER6.3999e-08image
ENSG00000249348.1,UGDH-AS1THCAEAG1.2049e-07image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr4:39530805-39535574:+LIHCPathEER3.9642e-033.6449e-04-0.2108image
ENSG00000249348.1,UGDH-AS1LIHCPathEAG3.7147e-033.3872e-04-0.2116image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for UGDH-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr4:39530805-39535574:+KICHEERENSG00000006757,PNPLA4-0.65743.0452e-039.3015e-05-0.4656imageNBUD13;DGCR8;ELAVL1;HNRNPC;IGF2BP1;IGF2BP2;LIN28B;NOP56;PTBP1;RBFOX2;SND1;SRSF1;TARDBP;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;AUHNADendritic_cells_restingGSVA_HALLMARK_FATTY_ACID_METABOLISM
chr4:39530805-39535574:+KICHEERENSG00000102241,HTATSF1-0.61041.7174e-028.0688e-05-0.4692imageNBUD13;DGCR8;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;RBM27;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;NONO;NUMA1;RANGAP1HTATSF1Macrophages_M2GSVA_HALLMARK_MYC_TARGETS_V1
chr4:39530805-39535574:+KICHEERENSG00000106603,COA1-0.60401.7536e-022.5836e-07-0.5881imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;RBM27;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NONO;NUMA1;RANGAP1;AUHNADendritic_cells_activatedGSVA_HALLMARK_MYC_TARGETS_V1
chr4:39530805-39535574:+KICHEERENSG00000105983,LMBR1-0.60801.7536e-026.5410e-07-0.5717imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NONO;NUMA1;RANGAP1;AUHNAT_cells_CD4_memory_restingGSVA_HALLMARK_PROTEIN_SECRETION
chr4:39530805-39535574:+KICHEERENSG00000136381,IREB2-0.60141.7536e-021.2543e-05-0.5128imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;RBM27;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NONO;NUMA1;RANGAP1;AUHNAT_cells_CD4_memory_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr4:39530805-39535574:+KICHEERENSG00000138796,HADH-0.59571.8562e-028.9945e-06-0.5201imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;SLTM;SND1;SRSF1;TARDBP;TIA1;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;RANGAP1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MTORC1_SIGNALING
chr4:39530805-39535574:+KICHEERENSG00000198919,DZIP3-0.58372.0354e-026.1565e-06-0.5281imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;FXR1;HNRNPC;IGF2BP1;IGF2BP2;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;SND1;SRSF1;TARDBP;TIA1;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NUMA1;RANGAP1NADendritic_cells_activatedGSVA_HALLMARK_PROTEIN_SECRETION
chr4:39530805-39535574:+KICHEERENSG00000140382,HMG20A-0.59302.0435e-021.9536e-06-0.5512imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;RBM27;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NONO;NUMA1;RANGAP1;AUHNAT_cells_follicular_helperGSVA_HALLMARK_PROTEIN_SECRETION
chr4:39530805-39535574:+KICHEERENSG00000198960,ARMCX6-0.57522.5241e-021.3910e-06-0.5577imageNBUD13;FBL;HNRNPA2B1;IGF2BP1;IGF2BP2;LIN28B;LSM11;NOP58;PTBP1;RBFOX2;SLTM;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;HNRNPK;NUMA1;RANGAP1NAT_cells_gamma_deltaGSVA_HALLMARK_SPERMATOGENESIS
chr4:39530805-39535574:+KICHEERENSG00000140259,MFAP1-0.56322.5241e-023.2817e-07-0.5840imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;NOP56;NOP58;PTBP1;RBFOX2;RBM27;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NONO;NUMA1;RANGAP1;AUHNAT_cells_CD4_memory_activatedGSVA_HALLMARK_DNA_REPAIR

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4. Enriched editing regions and immune related splicing for UGDH-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
ENSG00000249348.1,UGDH-AS1
KICHEAGMEXENSG00000178381.7chr71153072:1153224:1155452:1155489:1158157:1158257:1159963:11601530.61314.5286e-023.1690e-080.6221imageNADAR;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;SAFB2;SLTM;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_HEME_METABOLISM
chr4:39530805-39535574:+
KICHEERMEXENSG00000178381.7chr71153072:1153224:1155452:1155489:1158157:1158257:1159963:11601530.61004.1492e-023.6180e-080.6201imageNBUD13;DGCR8;ELAVL1;FBL;FXR1;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;LSM11;NOP56;NOP58;PTBP1;RBFOX2;SLTM;SND1;SRSF1;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;GTF2F1;HNRNPK;NONO;NUMA1;RANGAP1;AUHNAT_cells_CD4_memory_restingGSVA_HALLMARK_HEME_METABOLISM
chr4:39530805-39535574:+
KIRCEERMEXENSG00000204852.11chr12110641541:110641627:110642248:110642389:110644972:110647336:110647748:110647757-0.37192.8032e-102.3445e-16-0.4147imageNBUD13;DGCR8;DHX9;ELAVL1;FBL;HNRNPA2B1;HNRNPC;IGF2BP1;IGF2BP2;ILF3;LIN28B;NOP56;NOP58;PTBP1;RBFOX2;SND1;SRSF1;TARDBP;TIA1;U2AF1;U2AF2;UPF1;CSTF2T;FMR1;HNRNPK;NUMA1;RANGAP1;AUHNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_UV_RESPONSE_DN
ENSG00000249348.1,UGDH-AS1
KIRCEAGA3ENSG00000174705.7chr5172346135:172346261:172333498:172333769:172333498:1723399160.24692.2810e-064.7766e-170.4851imageNADAR;ALYREF;AUH;BUD13;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;LIN28A;LIN28B;MOV10;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM5;SLTM;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184SH3PXD2BT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000249348.1,UGDH-AS1
KIRCEAGMEXENSG00000022840.11chr12120557545:120557682:120560725:120560886:120571190:120571291:120575630:120575688-0.40708.1154e-131.6725e-17-0.4284imageNADAR;ALYREF;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;DKC1;EIF4A3;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000249348.1,UGDH-AS1
KIRCEAGMEXENSG00000147403.12chrX154399486:154399594:154399802:154399917:154400557:154400626:154400701:154400917-0.45886.4794e-171.2401e-19-0.4532imageNALYREF;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000249348.1,UGDH-AS1
KIRCEAGMEXENSG00000147403.12chrX154399486:154399594:154399802:154399917:154400563:154400626:154400701:154400917-0.45886.4794e-171.2401e-19-0.4532imageNALYREF;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000249348.1,UGDH-AS1
KIRCEAGMEXENSG00000198034.6chrX72273231:72273389:72273800:72273867:72273867:72273972:72275052:722751500.42208.2663e-141.6470e-160.4162imageNADAR;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DHX9;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RBM5;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_PROTEIN_SECRETION
ENSG00000249348.1,UGDH-AS1
KIRCEAGMEXENSG00000147403.12chrX154399486:154399594:154399802:154399925:154400474:154400626:154400701:154400917-0.45886.4794e-171.2401e-19-0.4532imageNALYREF;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE
ENSG00000249348.1,UGDH-AS1
KIRCEAGMEXENSG00000147403.12chrX154399486:154399594:154399802:154399925:154400557:154400626:154400701:154400917-0.45886.4794e-171.2401e-19-0.4532imageNALYREF;AUH;BUD13;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LIN28A;LIN28B;LSM11;MOV10;NONO;NOP56;NOP58;NUMA1;PCBP2;PTBP1;RANGAP1;RBFOX2;RBM10;RBM27;RBM5;SAFB2;SLTM;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_MITOTIC_SPINDLE

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5. Enriched editing regions and immune infiltration for UGDH-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr4:39530805-39535574:+BLCAEERT_cells_regulatory_(Tregs)9.5335e-030.1552image
ENSG00000249348.1,UGDH-AS1BLCAEAGT_cells_regulatory_(Tregs)9.6466e-030.1550image
chr4:39530805-39535574:+BRCAEERT_cells_gamma_delta5.9151e-040.1083image
chr4:39537084-39538448:+BRCAEERNK_cells_activated3.0020e-020.3312image
ENSG00000249348.1,UGDH-AS1BRCAEAGT_cells_gamma_delta5.7104e-040.1086image
chr4:39530805-39535574:+CESCEEREosinophils2.4958e-070.4167image
ENSG00000249348.1,UGDH-AS1CESCEAGEosinophils2.5207e-070.4166image
chr4:39530805-39535574:+CHOLEERT_cells_gamma_delta3.3296e-040.6027image
ENSG00000249348.1,UGDH-AS1CHOLEAGT_cells_gamma_delta3.2047e-040.6040image
chr4:39530805-39535574:+COADEERB_cells_memory2.9279e-020.1830image
ENSG00000249348.1,UGDH-AS1COADEAGB_cells_memory3.8510e-020.1739image
chr4:39530805-39535574:+ESCAEEREosinophils8.3383e-040.2963image
ENSG00000249348.1,UGDH-AS1ESCAEAGEosinophils8.4965e-040.2958image
chr4:39530805-39535574:+GBMEERPlasma_cells4.5408e-02-0.1636image
ENSG00000249348.1,UGDH-AS1GBMEAGPlasma_cells4.5770e-02-0.1634image
chr4:39530805-39535574:+HNSCEERT_cells_CD4_memory_resting2.7055e-02-0.1782image
ENSG00000249348.1,UGDH-AS1HNSCEAGT_cells_CD4_memory_resting2.6891e-02-0.1784image
chr4:39530805-39535574:+KICHEERT_cells_gamma_delta2.7325e-020.2738image
ENSG00000249348.1,UGDH-AS1KICHEAGT_cells_gamma_delta2.8312e-020.2721image
chr4:39530805-39535574:+KIRCEERT_cells_regulatory_(Tregs)5.9838e-100.3193image
ENSG00000249348.1,UGDH-AS1KIRCEAGT_cells_regulatory_(Tregs)8.4477e-100.3162image
chr4:39530805-39535574:+KIRPEERMonocytes3.0965e-02-0.1318image
ENSG00000249348.1,UGDH-AS1KIRPEAGMonocytes3.8096e-02-0.1268image
chr4:39530805-39535574:+LIHCEERMonocytes4.3573e-020.1162image
ENSG00000249348.1,UGDH-AS1LIHCEAGMonocytes4.8846e-020.1133image
chr4:39530805-39535574:+LUADEERT_cells_regulatory_(Tregs)1.5622e-030.1516image
ENSG00000249348.1,UGDH-AS1LUADEAGT_cells_regulatory_(Tregs)1.4493e-030.1526image
chr4:39530805-39535574:+LUSCEERT_cells_follicular_helper4.6594e-020.1103image
ENSG00000249348.1,UGDH-AS1LUSCEAGT_cells_follicular_helper4.5695e-020.1108image
chr4:39530805-39535574:+OVEERDendritic_cells_activated4.3578e-030.1717image
ENSG00000249348.1,UGDH-AS1OVEAGDendritic_cells_activated5.0977e-030.1688image
chr4:39530805-39535574:+PAADEERMonocytes2.5129e-030.2544image
ENSG00000249348.1,UGDH-AS1PAADEAGMonocytes2.4271e-030.2552image
chr4:39530805-39535574:+PCPGEERMacrophages_M23.4873e-020.1610image
ENSG00000249348.1,UGDH-AS1PCPGEAGMacrophages_M23.4573e-020.1613image
chr4:39530805-39535574:+PRADEERT_cells_CD4_memory_resting4.3418e-05-0.1827image
ENSG00000249348.1,UGDH-AS1PRADEAGT_cells_CD4_memory_resting6.1252e-05-0.1791image
chr4:39530805-39535574:+READEERNK_cells_activated6.4628e-050.4999image
ENSG00000249348.1,UGDH-AS1READEAGNK_cells_activated6.8622e-050.4984image
chr4:39530805-39535574:+SARCEERT_cells_CD4_memory_resting1.3715e-02-0.1671image
ENSG00000249348.1,UGDH-AS1SARCEAGT_cells_CD4_memory_resting1.2908e-02-0.1685image
chr4:39530805-39535574:+SKCMEERDendritic_cells_activated1.4121e-030.1647image
ENSG00000249348.1,UGDH-AS1SKCMEAGDendritic_cells_activated1.4080e-030.1648image
chr4:39530805-39535574:+STADEERMacrophages_M18.6434e-030.1601image
chr4:39545262-39546162:+STADEERT_cells_follicular_helper8.1975e-03-0.5166image
ENSG00000249348.1,UGDH-AS1STADEAGMacrophages_M17.6728e-030.1625image
chr4:39530805-39535574:+TGCTEERPlasma_cells6.4750e-030.3039image
ENSG00000249348.1,UGDH-AS1TGCTEAGPlasma_cells6.4180e-030.3042image
chr4:39530805-39535574:+THCAEERT_cells_regulatory_(Tregs)3.4294e-040.1603image
ENSG00000249348.1,UGDH-AS1THCAEAGT_cells_regulatory_(Tregs)3.3869e-040.1604image
chr4:39530805-39535574:+THYMEERT_cells_gamma_delta7.9798e-040.3269image
ENSG00000249348.1,UGDH-AS1THYMEAGT_cells_gamma_delta7.9810e-040.3269image
chr4:39530805-39535574:+UCECEERT_cells_regulatory_(Tregs)3.5043e-020.1689image
chr4:39530805-39535574:+UCSEERT_cells_CD81.0317e-030.4344image
ENSG00000249348.1,UGDH-AS1UCSEAGT_cells_CD81.0518e-030.4337image
chr4:39530805-39535574:+UVMEERT_cells_CD4_memory_resting3.2415e-030.3546image
ENSG00000249348.1,UGDH-AS1UVMEAGT_cells_CD4_memory_resting3.2415e-030.3546image


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6. Enriched editing regions and immune gene sets for UGDH-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr4:39530805-39535574:+ACCGSVA_HALLMARK_MITOTIC_SPINDLEEER5.6754e-03-0.3857image
ENSG00000249348.1,UGDH-AS1ACCGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.6754e-03-0.3857image
chr4:39530805-39535574:+BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEER4.7016e-03-0.1691image
ENSG00000249348.1,UGDH-AS1BLCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.6469e-03-0.1693image
ENSG00000249348.1,UGDH-AS1BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.1302e-130.2274image
chr4:39530805-39535574:+BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.1526e-130.2274image
chr4:39537084-39538448:+BRCAGSVA_HALLMARK_MYOGENESISEER1.6747e-040.5432image
ENSG00000249348.1,UGDH-AS1CHOLGSVA_HALLMARK_SPERMATOGENESISEAG3.3849e-020.3822image
chr4:39530805-39535574:+CHOLGSVA_HALLMARK_SPERMATOGENESISEER3.3016e-020.3839image
chr4:39530805-39535574:+COADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER1.9471e-02-0.1959image
ENSG00000249348.1,UGDH-AS1COADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.3092e-02-0.1906image
ENSG00000249348.1,UGDH-AS1ESCAGSVA_HALLMARK_UV_RESPONSE_UPEAG1.4211e-02-0.2197image
chr4:39530805-39535574:+ESCAGSVA_HALLMARK_UV_RESPONSE_UPEER1.5643e-02-0.2167image
ENSG00000249348.1,UGDH-AS1HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.2903e-030.2354image
chr4:39530805-39535574:+HNSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.2883e-030.2354image
chr4:39530805-39535574:+KICHGSVA_HALLMARK_MYC_TARGETS_V1EER5.5601e-04-0.4166image
ENSG00000249348.1,UGDH-AS1KICHGSVA_HALLMARK_MYC_TARGETS_V1EAG6.6253e-04-0.4114image
ENSG00000249348.1,UGDH-AS1KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.5304e-06-0.2451image
chr4:39530805-39535574:+KIRCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.8589e-06-0.2410image
ENSG00000249348.1,UGDH-AS1KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEAG7.7721e-06-0.2693image
chr4:39530805-39535574:+KIRPGSVA_HALLMARK_PROTEIN_SECRETIONEER2.5384e-05-0.2542image
ENSG00000249348.1,UGDH-AS1LGGGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.2801e-09-0.2534image
chr4:39530805-39535574:+LGGGSVA_HALLMARK_MITOTIC_SPINDLEEER8.9838e-09-0.2528image
chr4:39530805-39535574:+LIHCGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.9768e-030.1773image
ENSG00000249348.1,UGDH-AS1LIHCGSVA_HALLMARK_KRAS_SIGNALING_DNEAG1.8828e-030.1779image
ENSG00000249348.1,UGDH-AS1LUADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.7370e-02-0.1001image
chr4:39530805-39535574:+LUADGSVA_HALLMARK_UV_RESPONSE_DNEER4.1407e-02-0.0981image
ENSG00000249348.1,UGDH-AS1LUSCGSVA_HALLMARK_SPERMATOGENESISEAG2.5365e-04-0.2013image
chr4:39530805-39535574:+LUSCGSVA_HALLMARK_SPERMATOGENESISEER2.6726e-04-0.2006image
chr4:39530805-39535574:+OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.8170e-03-0.1631image
ENSG00000249348.1,UGDH-AS1OVGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0504e-02-0.1544image
ENSG00000249348.1,UGDH-AS1PAADGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.1683e-03-0.2416image
chr4:39530805-39535574:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1571e-03-0.2417image
chr4:39530805-39535574:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER1.4007e-04-0.2864image
ENSG00000249348.1,UGDH-AS1PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3861e-04-0.2865image
ENSG00000249348.1,UGDH-AS1PRADGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.5163e-12-0.3032image
chr4:39530805-39535574:+PRADGSVA_HALLMARK_MITOTIC_SPINDLEEER4.7518e-12-0.3041image
chr4:39530805-39535574:+READGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER6.1633e-03-0.3556image
ENSG00000249348.1,UGDH-AS1READGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG5.8032e-03-0.3579image
chr4:39530805-39535574:+SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2808e-060.3218image
ENSG00000249348.1,UGDH-AS1SARCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.2957e-060.3217image
chr4:39530805-39535574:+SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEER2.9967e-06-0.2391image
ENSG00000249348.1,UGDH-AS1SKCMGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.9968e-06-0.2391image
ENSG00000249348.1,UGDH-AS1STADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG6.6105e-040.2067image
chr4:39545262-39546162:+STADGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.4476e-020.4052image
chr4:39530805-39535574:+STADGSVA_HALLMARK_P53_PATHWAYEER3.2574e-040.2179image
chr4:39530805-39535574:+TGCTGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER3.0082e-020.2442image
ENSG00000249348.1,UGDH-AS1TGCTGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG3.0001e-020.2443image
chr4:39530805-39535574:+THCAGSVA_HALLMARK_HEME_METABOLISMEER9.3113e-12-0.3001image
ENSG00000249348.1,UGDH-AS1THCAGSVA_HALLMARK_HEME_METABOLISMEAG9.0493e-12-0.3002image
chr4:39530805-39535574:+THYMGSVA_HALLMARK_ANGIOGENESISEER3.8745e-03-0.2836image
ENSG00000249348.1,UGDH-AS1THYMGSVA_HALLMARK_ANGIOGENESISEAG3.8739e-03-0.2836image
chr4:39530805-39535574:+UCECGSVA_HALLMARK_UNFOLDED_PROTEIN_RESPONSEEER3.2855e-03-0.2340image
ENSG00000249348.1,UGDH-AS1UCECGSVA_HALLMARK_COAGULATIONEAG4.6111e-030.2257image
ENSG00000249348.1,UGDH-AS1UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG5.8035e-05-0.5190image
chr4:39530805-39535574:+UCSGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER6.6460e-05-0.5154image


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7. Enriched editing regions and drugs for UGDH-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr4:39530805-39535574:+ACCGemcitabineEER1.2338e-030.4441image
ENSG00000249348.1,UGDH-AS1ACCGemcitabineEAG1.2338e-030.4441image
ENSG00000249348.1,UGDH-AS1BLCACI.1040EAG3.6272e-03-0.1739image
chr4:39530805-39535574:+BLCACI.1040EER3.7289e-03-0.1734image
chr4:39530805-39535574:+BRCAAKT.inhibitor.VIIIEER3.5697e-090.1851image
ENSG00000249348.1,UGDH-AS1BRCAA.770041EAG3.6713e-09-0.1851image
chr4:39537084-39538448:+BRCAGSK269962AEER4.0327e-03-0.4297image
ENSG00000249348.1,UGDH-AS1CESCAKT.inhibitor.VIIIEAG4.5896e-030.2366image
chr4:39530805-39535574:+CESCAKT.inhibitor.VIIIEER4.4715e-030.2372image
ENSG00000249348.1,UGDH-AS1CHOLEmbelinEAG1.8048e-020.4220image
chr4:39530805-39535574:+CHOLEmbelinEER1.7498e-020.4238image
chr4:39530805-39535574:+COADBexaroteneEER4.8765e-020.1657image
chr4:39530805-39535574:+GBMBIBW2992EER1.5374e-02-0.1976image
ENSG00000249348.1,UGDH-AS1GBMBIBW2992EAG1.5646e-02-0.1971image
ENSG00000249348.1,UGDH-AS1HNSCCEP.701EAG8.7583e-04-0.2655image
chr4:39530805-39535574:+HNSCCEP.701EER8.9447e-04-0.2650image
chr4:39530805-39535574:+KICHGefitinibEER2.6974e-06-0.5449image
ENSG00000249348.1,UGDH-AS1KICHGefitinibEAG3.3604e-06-0.5405image
chr4:39530805-39535574:+KIRCGSK269962AEER5.1931e-11-0.3375image
ENSG00000249348.1,UGDH-AS1KIRCGSK269962AEAG6.7855e-10-0.3179image
ENSG00000249348.1,UGDH-AS1KIRPKU.55933EAG7.1961e-05-0.2401image
chr4:39530805-39535574:+KIRPKU.55933EER4.6875e-05-0.2460image
ENSG00000249348.1,UGDH-AS1LGGBX.795EAG9.2736e-070.2167image
chr4:39530805-39535574:+LGGBX.795EER8.9728e-070.2170image
chr4:39530805-39535574:+LIHCDasatinibEER5.5477e-06-0.2765image
ENSG00000249348.1,UGDH-AS1LIHCDasatinibEAG6.1902e-06-0.2746image
ENSG00000249348.1,UGDH-AS1LUADBryostatin.1EAG5.7904e-04-0.1647image
chr4:39530805-39535574:+LUADBryostatin.1EER5.5551e-04-0.1652image
ENSG00000249348.1,UGDH-AS1LUSCGefitinibEAG1.5204e-02-0.1343image
chr4:39530805-39535574:+LUSCGefitinibEER1.4724e-02-0.1350image
ENSG00000249348.1,UGDH-AS1MESOCHIR.99021EAG1.2879e-02-0.3167image
chr4:39530805-39535574:+MESOCHIR.99021EER1.2879e-02-0.3167image
chr4:39530805-39535574:+OVGefitinibEER6.4284e-03-0.1646image
ENSG00000249348.1,UGDH-AS1OVGefitinibEAG1.0138e-02-0.1554image
chr4:39545262-39546162:+OVCamptothecinEER2.4508e-020.3552image
ENSG00000249348.1,UGDH-AS1PAADGDC.0449EAG3.0414e-03-0.2532image
chr4:39530805-39535574:+PAADGDC.0449EER2.9768e-03-0.2538image
chr4:39530805-39535574:+PCPGBryostatin.1EER3.1283e-05-0.3118image
ENSG00000249348.1,UGDH-AS1PCPGBryostatin.1EAG3.7022e-05-0.3091image
ENSG00000249348.1,UGDH-AS1PRADBMS.509744EAG2.6376e-08-0.2468image
chr4:39530805-39535574:+PRADBMS.509744EER1.8717e-08-0.2494image
chr4:39530805-39535574:+READBosutinibEER3.0055e-020.2851image
ENSG00000249348.1,UGDH-AS1READCyclopamineEAG2.7303e-02-0.2924image
chr4:39530805-39535574:+SARCBAY.61.3606EER8.9635e-120.4416image
ENSG00000249348.1,UGDH-AS1SARCBAY.61.3606EAG7.0763e-120.4436image
chr4:39530805-39535574:+SKCMEmbelinEER1.4148e-040.1958image
ENSG00000249348.1,UGDH-AS1SKCMEmbelinEAG1.5206e-040.1949image
chr4:39530805-39535574:+STADBIBW2992EER6.5552e-04-0.2080image
chr4:39545262-39546162:+STADAUY922EER2.1985e-02-0.4559image
ENSG00000249348.1,UGDH-AS1STADBIBW2992EAG1.0512e-03-0.2002image
ENSG00000249348.1,UGDH-AS1TGCTBIBW2992EAG2.3266e-02-0.2551image
chr4:39530805-39535574:+TGCTBIBW2992EER2.3452e-02-0.2548image
ENSG00000249348.1,UGDH-AS1THCAAKT.inhibitor.VIIIEAG8.0098e-140.3273image
chr4:39530805-39535574:+THCAAKT.inhibitor.VIIIEER6.9600e-140.3281image
chr4:39530805-39535574:+THYMFTI.277EER3.6784e-030.2851image
ENSG00000249348.1,UGDH-AS1THYMFTI.277EAG3.6874e-030.2850image
ENSG00000249348.1,UGDH-AS1UCECGW.441756EAG2.0430e-030.2451image
chr4:39530805-39535574:+UCECGW.441756EER2.2124e-030.2433image
chr4:39530805-39535574:+UCSAZD6482EER9.6430e-060.5623image
ENSG00000249348.1,UGDH-AS1UCSAZD6482EAG1.1076e-050.5592image
ENSG00000249348.1,UGDH-AS1UVMGSK269962AEAG2.1249e-03-0.3689image
chr4:39530805-39535574:+UVMGSK269962AEER2.1249e-03-0.3689image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType