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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

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6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: TPTE2P5 (ImmuneEditome ID:100616668)

1. Gene summary of enriched editing regions for TPTE2P5

check button Gene summary
Gene informationGene symbol

TPTE2P5

Gene ID

100616668

GeneSynonyms-
GeneCytomap

13q14.11

GeneTypepseudo
GeneDescriptionTPTE2 pseudogene|transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr13:40848183-40848776:-ENST00000379515.3ENSG00000168852.11TPTE2P5ncRNA_intronic(AC)n,AluSz6,AluJb,L1MEgchr13:40848183-40848776:-.alignment
chr13:40848183-40848776:-ENST00000432905.4ENSG00000168852.11TPTE2P5ncRNA_intronic(AC)n,AluSz6,AluJb,L1MEgchr13:40848183-40848776:-.alignment
chr13:40848183-40848776:-ENST00000458118.4ENSG00000168852.11TPTE2P5ncRNA_intronic(AC)n,AluSz6,AluJb,L1MEgchr13:40848183-40848776:-.alignment
chr13:40857832-40858006:-ENST00000379515.3ENSG00000168852.11TPTE2P5ncRNA_intronicAluSq2,AluYchr13:40857832-40858006:-.alignment
chr13:40857832-40858006:-ENST00000458118.4ENSG00000168852.11TPTE2P5ncRNA_intronicAluSq2,AluYchr13:40857832-40858006:-.alignment
chr13:40881505-40881716:-ENST00000379515.3ENSG00000168852.11TPTE2P5ncRNA_intronicMSTB,AluSzchr13:40881505-40881716:-.alignment
chr13:40893029-40896142:-ENST00000379515.3ENSG00000168852.11TPTE2P5ncRNA_intronicL2a,(AC)n,L1PA5,AluSx,AluJr,FRAM,AluSp,AluSc8chr13:40893029-40896142:-.alignment
chr13:40905482-40907818:-ENST00000379515.3ENSG00000168852.11TPTE2P5ncRNA_intronicAluSx,AluJo,AluSx3,MIR3,AluSx1chr13:40905482-40907818:-.alignment
chr13:40919490-40920182:-ENST00000379515.3ENSG00000168852.11TPTE2P5ncRNA_intronicAluSz,L1ME3,(TAA)n,AluSxchr13:40919490-40920182:-.alignment


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2. Tumor-specific enriched editing regions for TPTE2P5


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr13:40919490-40920182:-THCAEER1.0030e-04image
ENSG00000168852.11,TPTE2P5THCAEAG7.0879e-06image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr13:40919490-40920182:-ESCAEER7.7546e-033.5906e-023.5439e-05image

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3. Enriched editing regions and immune related genes for TPTE2P5


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for TPTE2P5


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for TPTE2P5


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr13:40919490-40920182:-BRCAEERDendritic_cells_activated2.9208e-02-0.2119image
ENSG00000168852.11,TPTE2P5COADEAGT_cells_follicular_helper2.6862e-020.3544image
chr13:40919490-40920182:-GBMEERMacrophages_M02.0762e-03-0.3962image
ENSG00000168852.11,TPTE2P5GBMEAGMacrophages_M02.0762e-03-0.3962image
chr13:40919490-40920182:-LGGEERT_cells_regulatory_(Tregs)3.8451e-02-0.1137image
ENSG00000168852.11,TPTE2P5LGGEAGEosinophils3.3359e-020.1168image
chr13:40919490-40920182:-LUADEERMacrophages_M11.3269e-030.5507image
ENSG00000168852.11,TPTE2P5LUADEAGNeutrophils4.8718e-040.4938image
chr13:40919490-40920182:-OVEERDendritic_cells_resting2.5653e-040.3347image
ENSG00000168852.11,TPTE2P5OVEAGDendritic_cells_resting1.0226e-040.3458image
ENSG00000168852.11,TPTE2P5PAADEAGB_cells_memory1.3489e-020.4970image
chr13:40919490-40920182:-PCPGEERT_cells_regulatory_(Tregs)2.9791e-020.3576image
chr13:40919490-40920182:-SKCMEERMast_cells_activated2.5680e-020.3288image
ENSG00000168852.11,TPTE2P5SKCMEAGMast_cells_activated2.2407e-020.3290image
chr13:40881505-40881716:-STADEERT_cells_gamma_delta2.5331e-020.3624image
chr13:40919490-40920182:-STADEERNeutrophils5.9711e-030.2846image
chr13:40919490-40920182:-THCAEERT_cells_gamma_delta2.5703e-020.1168image
ENSG00000168852.11,TPTE2P5THCAEAGT_cells_gamma_delta2.5705e-020.1150image
ENSG00000168852.11,TPTE2P5THYMEAGMacrophages_M03.6119e-020.3324image
chr13:40919490-40920182:-UCECEERMast_cells_activated1.5437e-02-0.3514image
ENSG00000168852.11,TPTE2P5UCECEAGDendritic_cells_activated4.1692e-03-0.3739image
chr13:40919490-40920182:-UCSEERDendritic_cells_activated4.4603e-020.4424image
ENSG00000168852.11,TPTE2P5UCSEAGDendritic_cells_activated4.0010e-020.4513image


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6. Enriched editing regions and immune gene sets for TPTE2P5


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr13:40919490-40920182:-BRCAGSVA_HALLMARK_COAGULATIONEER3.1086e-040.3436image
ENSG00000168852.11,TPTE2P5BRCAGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG1.4798e-040.3232image
ENSG00000168852.11,TPTE2P5COADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.6329e-02-0.3822image
chr13:40919490-40920182:-GBMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER4.9809e-030.3639image
ENSG00000168852.11,TPTE2P5GBMGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG4.9809e-030.3639image
ENSG00000168852.11,TPTE2P5LAMLGSVA_HALLMARK_GLYCOLYSISEAG3.2829e-030.3084image
chr13:40919490-40920182:-LGGGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.4711e-030.1739image
ENSG00000168852.11,TPTE2P5LGGGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.5438e-030.1731image
chr13:40919490-40920182:-LUADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER4.0424e-020.3701image
ENSG00000168852.11,TPTE2P5PCPGGSVA_HALLMARK_APICAL_SURFACEEAG4.0958e-02-0.3288image
chr13:40919490-40920182:-PCPGGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEER4.7587e-020.3279image
chr13:40919490-40920182:-PRADGSVA_HALLMARK_PEROXISOMEEER2.7934e-020.1676image
ENSG00000168852.11,TPTE2P5PRADGSVA_HALLMARK_PEROXISOMEEAG3.7790e-020.1563image
ENSG00000168852.11,TPTE2P5SKCMGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.9812e-03-0.4081image
chr13:40919490-40920182:-SKCMGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER1.6748e-03-0.4506image
chr13:40893029-40896142:-STADGSVA_HALLMARK_GLYCOLYSISEER3.0279e-020.2872image
chr13:40919490-40920182:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.4304e-020.2546image
chr13:40905482-40907818:-STADGSVA_HALLMARK_TGF_BETA_SIGNALINGEER3.3817e-040.6592image
ENSG00000168852.11,TPTE2P5STADGSVA_HALLMARK_MYOGENESISEAG8.1569e-030.2111image
ENSG00000168852.11,TPTE2P5THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6252e-030.1620image
chr13:40919490-40920182:-THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.6600e-040.1855image
ENSG00000168852.11,TPTE2P5THYMGSVA_HALLMARK_PROTEIN_SECRETIONEAG8.1770e-03-0.4124image
chr13:40919490-40920182:-UCECGSVA_HALLMARK_FATTY_ACID_METABOLISMEER5.9120e-030.3956image
chr13:40919490-40920182:-UCSGSVA_HALLMARK_GLYCOLYSISEER1.8289e-020.5096image
ENSG00000168852.11,TPTE2P5UCSGSVA_HALLMARK_GLYCOLYSISEAG1.7386e-020.5130image


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7. Enriched editing regions and drugs for TPTE2P5


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
chr13:40919490-40920182:-BRCAABT.888EER2.0034e-040.3536image
ENSG00000168852.11,TPTE2P5BRCAABT.888EAG3.6634e-050.3498image
ENSG00000168852.11,TPTE2P5COADBryostatin.1EAG1.9098e-02-0.3737image
ENSG00000168852.11,TPTE2P5ESCAEHT.1864EAG1.8801e-02-0.3312image
chr13:40919490-40920182:-GBMBIBW2992EER2.7971e-02-0.2887image
ENSG00000168852.11,TPTE2P5GBMBIBW2992EAG2.7971e-02-0.2887image
ENSG00000168852.11,TPTE2P5LAMLAZD6244EAG8.2552e-04-0.3482image
chr13:40919490-40920182:-LGGLapatinibEER3.1128e-04-0.1967image
ENSG00000168852.11,TPTE2P5LGGLapatinibEAG3.2948e-04-0.1959image
ENSG00000168852.11,TPTE2P5LUADGemcitabineEAG8.2381e-03-0.3850image
chr13:40919490-40920182:-OVBIRB.0796EER4.5718e-02-0.1867image
ENSG00000168852.11,TPTE2P5PAADATRAEAG3.7117e-030.5801image
ENSG00000168852.11,TPTE2P5PCPGATRAEAG1.6616e-020.3813image
chr13:40919490-40920182:-PCPGAG.014699EER3.6611e-020.3448image
chr13:40919490-40920182:-PRADAMG.706EER4.4505e-020.1534image
ENSG00000168852.11,TPTE2P5SKCMBIBW2992EAG5.5918e-03-0.3940image
chr13:40919490-40920182:-SKCMBIBW2992EER5.8349e-03-0.4004image
chr13:40893029-40896142:-STADAZ628EER3.1050e-02-0.2860image
chr13:40881505-40881716:-STADBI.D1870EER4.5831e-02-0.3259image
ENSG00000168852.11,TPTE2P5STADBexaroteneEAG7.2214e-03-0.2143image
ENSG00000168852.11,TPTE2P5THCABMS.536924EAG1.2981e-03-0.1655image
chr13:40919490-40920182:-THCAEmbelinEER1.1342e-020.1324image
ENSG00000168852.11,TPTE2P5THYMAZD6244EAG5.5398e-04-0.5218image
ENSG00000168852.11,TPTE2P5UCECAxitinibEAG1.7191e-020.3145image
chr13:40919490-40920182:-UCECElesclomolEER3.9101e-020.3020image
chr13:40919490-40920182:-UCSAUY922EER6.5766e-03-0.5734image
ENSG00000168852.11,TPTE2P5UCSAUY922EAG7.4823e-03-0.5660image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType