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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: BCL2L2-PABPN1 (ImmuneEditome ID:100529063)

1. Gene summary of enriched editing regions for BCL2L2-PABPN1

check button Gene summary
Gene informationGene symbol

BCL2L2-PABPN1

Gene ID

100529063

GeneSynonyms-
GeneCytomap

14q11.2

GeneTypeprotein-coding
GeneDescriptionBCL2L2-PABPN1 protein
GeneModificationdate20230329
UniprotIDA0A7I2V383
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr14:23314154-23314359:+ENST00000556100.2ENSG00000258643.4BCL2L2-PABPN1ncRNA_intronicAluScchr14:23314154-23314359:+.alignment
chr14:23317161-23319392:+ENST00000556100.2ENSG00000258643.4BCL2L2-PABPN1ncRNA_intronic(TA)n,AluJo,AluSx,L1ME4a,MIRb,AluSx1chr14:23317161-23319392:+.alignment


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2. Tumor-specific enriched editing regions for BCL2L2-PABPN1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for BCL2L2-PABPN1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for BCL2L2-PABPN1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for BCL2L2-PABPN1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr14:23317161-23319392:+BRCAEERPlasma_cells1.0946e-050.4058image
ENSG00000258643.4,BCL2L2-PABPN1BRCAEAGPlasma_cells5.1887e-050.3565image
chr14:23317161-23319392:+CESCEERB_cells_memory1.1584e-040.7559image
ENSG00000258643.4,BCL2L2-PABPN1CESCEAGB_cells_memory1.1696e-040.7556image
chr14:23317161-23319392:+ESCAEERB_cells_memory1.3343e-020.4328image
ENSG00000258643.4,BCL2L2-PABPN1ESCAEAGMacrophages_M24.9900e-020.3121image
chr14:23317161-23319392:+GBMEERT_cells_CD4_naive1.1542e-020.3862image
ENSG00000258643.4,BCL2L2-PABPN1GBMEAGT_cells_CD4_naive1.2832e-020.3809image
chr14:23317161-23319392:+LGGEERNK_cells_activated3.0547e-020.1538image
ENSG00000258643.4,BCL2L2-PABPN1LGGEAGNK_cells_activated2.9243e-020.1542image
ENSG00000258643.4,BCL2L2-PABPN1LUSCEAGT_cells_regulatory_(Tregs)7.4435e-030.5321image
ENSG00000258643.4,BCL2L2-PABPN1OVEAGB_cells_memory1.9784e-020.3287image
chr14:23317161-23319392:+PRADEERT_cells_CD4_memory_resting2.6009e-020.1607image
chr14:23317161-23319392:+SARCEERT_cells_follicular_helper1.8959e-020.4406image
ENSG00000258643.4,BCL2L2-PABPN1SARCEAGT_cells_follicular_helper1.4571e-020.4489image
chr14:23317161-23319392:+SKCMEERMacrophages_M14.8156e-030.3963image
ENSG00000258643.4,BCL2L2-PABPN1SKCMEAGMacrophages_M12.9506e-030.4043image
chr14:23317161-23319392:+STADEERNeutrophils4.5962e-030.4063image
ENSG00000258643.4,BCL2L2-PABPN1STADEAGNK_cells_resting3.7999e-020.2756image


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6. Enriched editing regions and immune gene sets for BCL2L2-PABPN1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000258643.4,BCL2L2-PABPN1BRCAGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG1.0834e-020.2290image
ENSG00000258643.4,BCL2L2-PABPN1CESCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEAG3.0554e-020.4841image
chr14:23317161-23319392:+CESCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER3.1962e-020.4806image
ENSG00000258643.4,BCL2L2-PABPN1ESCAGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.3911e-020.3362image
chr14:23317161-23319392:+KIRCGSVA_HALLMARK_ESTROGEN_RESPONSE_LATEEER4.4570e-020.2582image
ENSG00000258643.4,BCL2L2-PABPN1KIRPGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.1032e-020.3551image
chr14:23317161-23319392:+KIRPGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER2.2378e-020.3517image
chr14:23317161-23319392:+LGGGSVA_HALLMARK_NOTCH_SIGNALINGEER3.4809e-02-0.1501image
ENSG00000258643.4,BCL2L2-PABPN1LGGGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.1358e-02-0.1523image
chr14:23317161-23319392:+LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.9226e-030.4291image
ENSG00000258643.4,BCL2L2-PABPN1LUADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.8139e-030.4303image
ENSG00000258643.4,BCL2L2-PABPN1LUSCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG3.5541e-02-0.4309image
chr14:23317161-23319392:+PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.7991e-030.6268image
ENSG00000258643.4,BCL2L2-PABPN1PAADGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG1.1883e-030.6330image
chr14:23317161-23319392:+PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEER2.7990e-030.2728image
ENSG00000258643.4,BCL2L2-PABPN1PCPGGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.2914e-020.2273image
chr14:23317161-23319392:+PRADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER4.6419e-030.2035image
ENSG00000258643.4,BCL2L2-PABPN1PRADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG1.5581e-030.2257image
chr14:23317161-23319392:+SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.2177e-030.4488image
ENSG00000258643.4,BCL2L2-PABPN1SKCMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.5955e-030.4270image
chr14:23317161-23319392:+STADGSVA_HALLMARK_PANCREAS_BETA_CELLSEER1.5794e-020.3503image
ENSG00000258643.4,BCL2L2-PABPN1STADGSVA_HALLMARK_PANCREAS_BETA_CELLSEAG8.8646e-030.3436image
ENSG00000258643.4,BCL2L2-PABPN1THCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.9445e-020.2063image
chr14:23317161-23319392:+THCAGSVA_HALLMARK_PROTEIN_SECRETIONEER1.3372e-020.2491image


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7. Enriched editing regions and drugs for BCL2L2-PABPN1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000258643.4,BCL2L2-PABPN1BRCACCT018159EAG1.4614e-03-0.2839image
chr14:23317161-23319392:+BRCACCT018159EER1.1764e-02-0.2394image
ENSG00000258643.4,BCL2L2-PABPN1CESCCEP.701EAG5.6038e-04-0.7020image
chr14:23317161-23319392:+CESCCEP.701EER5.3247e-04-0.7039image
chr14:23317161-23319392:+ESCAAZD8055EER9.1080e-03-0.4537image
ENSG00000258643.4,BCL2L2-PABPN1ESCAAZD8055EAG5.3078e-03-0.4326image
ENSG00000258643.4,BCL2L2-PABPN1GBMGSK269962AEAG1.1229e-02-0.3875image
chr14:23317161-23319392:+GBMGSK269962AEER1.3710e-02-0.3775image
ENSG00000258643.4,BCL2L2-PABPN1KIRCFTI.277EAG1.9156e-03-0.3751image
chr14:23317161-23319392:+KIRCFTI.277EER4.2443e-03-0.3611image
ENSG00000258643.4,BCL2L2-PABPN1KIRPAICAREAG1.4430e-03-0.4760image
chr14:23317161-23319392:+KIRPAICAREER1.5495e-03-0.4732image
chr14:23317161-23319392:+LGGFTI.277EER2.0647e-030.2177image
ENSG00000258643.4,BCL2L2-PABPN1LGGFTI.277EAG2.4146e-030.2134image
ENSG00000258643.4,BCL2L2-PABPN1OVGefitinibEAG2.7873e-020.3111image
chr14:23317161-23319392:+OVGSK.650394EER3.2929e-02-0.3298image
chr14:23317161-23319392:+PAADFTI.277EER4.2227e-02-0.4366image
ENSG00000258643.4,BCL2L2-PABPN1PAADFTI.277EAG3.8258e-02-0.4346image
chr14:23317161-23319392:+PCPGCGP.60474EER1.4018e-030.2908image
ENSG00000258643.4,BCL2L2-PABPN1PCPGBortezomibEAG3.3151e-030.2671image
chr14:23317161-23319392:+PRADAZD.0530EER6.2875e-03-0.1991image
ENSG00000258643.4,BCL2L2-PABPN1PRADAZD.0530EAG1.7709e-02-0.1724image
chr14:23317161-23319392:+SKCMAZD6482EER2.8694e-03-0.4171image
ENSG00000258643.4,BCL2L2-PABPN1SKCMAZD6482EAG5.8106e-03-0.3774image
chr14:23317161-23319392:+STADAZ628EER1.7546e-020.3450image
ENSG00000258643.4,BCL2L2-PABPN1STADAZ628EAG7.8833e-030.3485image
ENSG00000258643.4,BCL2L2-PABPN1THCABicalutamideEAG5.8606e-03-0.2737image
chr14:23317161-23319392:+THCABicalutamideEER4.3108e-03-0.2860image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType