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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: RBM14-RBM4 (ImmuneEditome ID:100526737)

1. Gene summary of enriched editing regions for RBM14-RBM4

check button Gene summary
Gene informationGene symbol

RBM14-RBM4

Gene ID

100526737

GeneSynonymsCOAZ|PSP2|RBM14|SIP
GeneCytomap

11q13.2

GeneTypeprotein-coding
GeneDescriptionRBM14-RBM4 protein|Paraspeckle protein 2|RBM14/RBM4 fusion|RNA-binding motif protein 14|RNA-binding protein 14|RRM-containing coactivator activator/modulator|SYT-interacting protein|Synaptotagmin-interacting protein|transcriptional coactivator CoAZ
GeneModificationdate20230329
UniprotIDA0A0A0MSL8;A0A0A6YYI9
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:66629799-66637364:+ENST00000511114.1ENSG00000248643.5RBM14-RBM4ncRNA_intronicMIR1_Amn,(TCAT)n,MIRb,MIR,AluSp,AluY,AluJb,AluJr4,AluSx3,AluSx,AluJo,AluSg,AluSq2,AluSz,FLAM_A,L2achr11:66629799-66637364:+.alignment


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2. Tumor-specific enriched editing regions for RBM14-RBM4


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr11:66629799-66637364:+THCAEER4.5776e-02image
ENSG00000248643.5,RBM14-RBM4THCAEAG4.5776e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
chr11:66629799-66637364:+LUADPathEER4.4867e-034.0334e-030.1995image
ENSG00000248643.5,RBM14-RBM4LUADPathEAG4.5009e-034.0100e-030.1997image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for RBM14-RBM4


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr11:66629799-66637364:+STADEERENSG00000200953,Y_RNA-0.43108.7812e-119.0474e-13-0.4027imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEME_METABOLISM
chr11:66629799-66637364:+STADEERENSG00000263466,RP1-56K13.2-0.42801.4475e-106.5589e-13-0.4049imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HEME_METABOLISM
chr11:66629799-66637364:+STADEERENSG00000257122,RRN3P3-0.41596.4611e-102.2256e-13-0.4124imageNNNAB_cells_memoryGSVA_HALLMARK_ADIPOGENESIS
chr11:66629799-66637364:+ESCAEERENSG00000200953,Y_RNA-0.44251.9026e-051.0136e-08-0.4362imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_GLYCOLYSIS
chr11:66629799-66637364:+ESCAEERENSG00000257246,RP11-416A17.6-0.39672.9971e-041.4663e-07-0.4035imageNNNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_P53_PATHWAY
chr11:66629799-66637364:+ESCAEERENSG00000188883,KLRG20.27252.2601e-026.8464e-110.4893imageNADAR;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FUS;HNRNPC;IGF2BP2;NOP56;PTBP1;RBFOX2;SRSF1;TAF15;U2AF2;UPF1;TARDBP;CSTF2TNADendritic_cells_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr11:66629799-66637364:+ESCAEERENSG00000072832,CRMP10.27543.0244e-026.0138e-090.4422imageNADAR;DGCR8;DKC1;EIF4A3;ELAVL1;FUS;FXR2;HNRNPC;IGF2BP2;PTBP1;RBFOX2;RBM10;RBM5;TAF15;TIA1;U2AF2;UPF1;TARDBP;CSTF2TNADendritic_cells_restingGSVA_HALLMARK_HEDGEHOG_SIGNALING

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4. Enriched editing regions and immune related splicing for RBM14-RBM4


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr11:66629799-66637364:+
ESCAEERIRENSG00000164576.7chr5154451090:154452499:154453401:154453485-0.28342.7547e-022.8471e-06-0.4224imageNADAR;CPSF6;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FUS;FXR2;HNRNPC;HNRNPK;IGF2BP2;NOP56;PRPF8;PTBP1;RBFOX2;RBM10;SF3A3;SF3B4;SMNDC1;SRSF1;SRSF7;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;SRSF9;TARDBP;CSTF2TNAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
ENSG00000248643.5,RBM14-RBM4
ESCAEAGIRENSG00000174720.11chr4112646790:112647127:112647198:112647449-0.42136.6810e-045.8560e-09-0.4425imageNACIN1;ADAR;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G1;EIF4G2;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RBFOX2;RBM10;RBM22;RBM47;RBM6;RNF219;SAFB2;SF3A3;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZC3H7B;ZNF184NADendritic_cells_activatedGSVA_HALLMARK_MTORC1_SIGNALING
ENSG00000248643.5,RBM14-RBM4
ESCAEAGIRENSG00000132950.14chr1319835476:19835689:19837655:19837821-0.41741.2285e-045.3734e-07-0.4128imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;ELAVL1;ELAVL3;EWSR1;FAM120A;FBL;FMR1;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MBNL2;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;ZNF184NADendritic_cells_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000248643.5,RBM14-RBM4
ESCAEAGIRENSG00000016864.12chr352694488:52695302:52695420:52695554-0.42754.5126e-048.2821e-08-0.4108imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CBX7;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;METTL3;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM27;RBM47;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_JUNCTION
ENSG00000248643.5,RBM14-RBM4
ESCAEAGIRENSG00000164576.7chr5154451090:154452499:154453401:154453485-0.28363.2709e-022.6166e-06-0.4238imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX54;DGCR8;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LIN28;LIN28A;LIN28B;MBNL2;MOV10;MSI2;NOP56;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM47;RNF219;RTCB;SAFB2;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YTHDF1;ZC3H7B;ZNF184NAT_cells_regulatory_(Tregs)GSVA_HALLMARK_HYPOXIA
chr11:66629799-66637364:+
ESCAEERIRENSG00000016864.12chr352694488:52695302:52695420:52695554-0.42644.3447e-048.6702e-08-0.4102imageNADAR;CPSF6;DDX54;DGCR8;DKC1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FUS;FXR2;HNRNPC;HNRNPK;IGF2BP2;MSI1;NOP56;PRPF8;PTBP1;RBFOX2;RBM10;RBM27;SF3A3;SF3B4;SMNDC1;SRSF1;SRSF7;TAF15;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;YWHAG;ACIN1;SRSF9;TARDBP;CSTF2TNAT_cells_CD4_memory_restingGSVA_HALLMARK_APICAL_JUNCTION
chr11:66629799-66637364:+
ESCAEERIRENSG00000132950.14chr1319835476:19835689:19837655:19837821-0.41551.2630e-045.5784e-07-0.4122imageNADAR;CPSF6;DDX54;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FUS;FXR2;HNRNPC;HNRNPK;IGF2BP2;MSI1;NOP56;NPM1;PRPF8;PTBP1;RBFOX2;RBM10;SF3B4;SMNDC1;SRSF1;SRSF7;TAF15;TIA1;TIAL1;TRA2A;U2AF1;U2AF2;UPF1;XRN2;SRSF9;TARDBP;CSTF2TNADendritic_cells_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000248643.5,RBM14-RBM4
ESCAEAGIRENSG00000119431.5chr9113375452:113375567:113376728:113376925-0.42278.3120e-047.5811e-08-0.4143imageNAUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FKBP4;FMR1;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;LARP4B;LIN28;LSM11;METTL3;NOP58;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM27;RNF219;SAFB2;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;XRN2;YTHDC1;YTHDF1;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_GLYCOLYSIS
chr11:66629799-66637364:+
ESCAEERIRENSG00000136040.4chr1294303755:94303896:94303976:94304051-0.35131.7370e-032.5278e-06-0.4177imageNADAR;DGCR8;DKC1;EIF4A3;ELAVL1;FAM120A;FUS;HNRNPC;HNRNPK;IGF2BP2;NOP56;PRPF8;PTBP1;RBFOX2;SF3A3;SF3B4;SMNDC1;SRSF1;SRSF7;TAF15;TIA1;TRA2A;U2AF1;U2AF2;UPF1;ACIN1;SRSF9;TARDBP;CSTF2TPLXNC1Macrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
ENSG00000248643.5,RBM14-RBM4
ESCAEAGIRENSG00000136040.4chr1294303755:94303896:94303976:94304051-0.35241.8686e-032.5645e-06-0.4174imageNACIN1;ADAR;AUH;BCCIP;BUD13;CNBP;CSTF2T;DGCR8;DKC1;EIF4A3;ELAVL1;EWSR1;FAM120A;FBL;FKBP4;FMR1;FUS;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPL;HNRNPM;IGF2BP1;IGF2BP2;IGF2BP3;KHDRBS1;KHDRBS2;LARP7;LIN28B;MBNL2;MOV10;MSI2;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM47;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TRA2A;U2AF1;U2AF2;UPF1;YTHDC1PLXNC1Macrophages_M1GSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

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5. Enriched editing regions and immune infiltration for RBM14-RBM4


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr11:66629799-66637364:+BRCAEERB_cells_memory1.8866e-02-0.1201image
ENSG00000248643.5,RBM14-RBM4BRCAEAGB_cells_memory1.7557e-02-0.1213image
chr11:66629799-66637364:+COADEERMast_cells_activated2.6268e-020.2532image
ENSG00000248643.5,RBM14-RBM4COADEAGMast_cells_activated2.6268e-020.2532image
chr11:66629799-66637364:+ESCAEERT_cells_regulatory_(Tregs)2.9023e-02-0.1737image
ENSG00000248643.5,RBM14-RBM4ESCAEAGT_cells_regulatory_(Tregs)3.0213e-02-0.1725image
chr11:66629799-66637364:+GBMEERT_cells_regulatory_(Tregs)4.4819e-040.4292image
ENSG00000248643.5,RBM14-RBM4GBMEAGT_cells_regulatory_(Tregs)4.4819e-040.4292image
chr11:66629799-66637364:+KIRCEERDendritic_cells_resting3.2773e-030.2871image
ENSG00000248643.5,RBM14-RBM4KIRCEAGDendritic_cells_resting3.2773e-030.2871image
chr11:66629799-66637364:+LAMLEERNeutrophils2.0613e-020.1889image
ENSG00000248643.5,RBM14-RBM4LAMLEAGNeutrophils2.7326e-020.1802image
chr11:66629799-66637364:+LGGEEREosinophils1.3012e-020.1684image
ENSG00000248643.5,RBM14-RBM4LGGEAGEosinophils1.2259e-020.1698image
ENSG00000248643.5,RBM14-RBM4LIHCEAGEosinophils1.8573e-020.4203image
chr11:66629799-66637364:+LUSCEERT_cells_follicular_helper1.5243e-02-0.1869image
ENSG00000248643.5,RBM14-RBM4LUSCEAGT_cells_follicular_helper1.5243e-02-0.1869image
chr11:66629799-66637364:+OVEERT_cells_gamma_delta1.6665e-020.1522image
ENSG00000248643.5,RBM14-RBM4OVEAGT_cells_gamma_delta1.6661e-020.1522image
chr11:66629799-66637364:+PAADEEREosinophils3.7277e-040.4629image
ENSG00000248643.5,RBM14-RBM4PAADEAGEosinophils3.7277e-040.4629image
chr11:66629799-66637364:+SARCEERNeutrophils1.3034e-020.3019image
ENSG00000248643.5,RBM14-RBM4SARCEAGNeutrophils1.3034e-020.3019image
chr11:66629799-66637364:+SKCMEERNK_cells_activated1.6525e-020.2817image
ENSG00000248643.5,RBM14-RBM4SKCMEAGNK_cells_activated1.6525e-020.2817image
chr11:66629799-66637364:+STADEERB_cells_memory1.2462e-02-0.1463image
ENSG00000248643.5,RBM14-RBM4STADEAGB_cells_memory1.2580e-02-0.1461image
chr11:66629799-66637364:+THCAEERT_cells_CD4_memory_activated3.2006e-020.1868image
ENSG00000248643.5,RBM14-RBM4THCAEAGT_cells_CD4_memory_activated3.2006e-020.1868image
chr11:66629799-66637364:+THYMEERT_cells_CD4_memory_resting8.2447e-040.4204image
ENSG00000248643.5,RBM14-RBM4THYMEAGT_cells_CD4_memory_resting8.2447e-040.4204image
ENSG00000248643.5,RBM14-RBM4UCSEAGT_cells_regulatory_(Tregs)4.1479e-020.4282image


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6. Enriched editing regions and immune gene sets for RBM14-RBM4


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000248643.5,RBM14-RBM4BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.2280e-030.2200image
chr11:66629799-66637364:+BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2280e-030.2200image
chr11:66629799-66637364:+BRCAGSVA_HALLMARK_HEME_METABOLISMEER2.5416e-050.2137image
ENSG00000248643.5,RBM14-RBM4BRCAGSVA_HALLMARK_HEME_METABOLISMEAG2.1200e-050.2154image
ENSG00000248643.5,RBM14-RBM4COADGSVA_HALLMARK_ANGIOGENESISEAG7.8578e-030.3008image
chr11:66629799-66637364:+COADGSVA_HALLMARK_ANGIOGENESISEER7.8578e-030.3008image
chr11:66629799-66637364:+ESCAGSVA_HALLMARK_APICAL_JUNCTIONEER2.7054e-050.3272image
ENSG00000248643.5,RBM14-RBM4ESCAGSVA_HALLMARK_APICAL_JUNCTIONEAG2.5460e-050.3283image
chr11:66629799-66637364:+GBMGSVA_HALLMARK_MITOTIC_SPINDLEEER8.4178e-030.3292image
ENSG00000248643.5,RBM14-RBM4GBMGSVA_HALLMARK_MITOTIC_SPINDLEEAG8.4178e-030.3292image
chr11:66629799-66637364:+HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEER3.7877e-030.2751image
ENSG00000248643.5,RBM14-RBM4HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG3.7877e-030.2751image
chr11:66629799-66637364:+KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.7791e-020.2331image
ENSG00000248643.5,RBM14-RBM4KIRCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.7791e-020.2331image
chr11:66629799-66637364:+LAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEER3.6785e-030.2358image
ENSG00000248643.5,RBM14-RBM4LAMLGSVA_HALLMARK_BILE_ACID_METABOLISMEAG2.3721e-030.2464image
ENSG00000248643.5,RBM14-RBM4LIHCGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.7122e-02-0.4251image
chr11:66629799-66637364:+LUSCGSVA_HALLMARK_DNA_REPAIREER3.3097e-05-0.3144image
ENSG00000248643.5,RBM14-RBM4LUSCGSVA_HALLMARK_DNA_REPAIREAG3.3097e-05-0.3144image
ENSG00000248643.5,RBM14-RBM4OVGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.0013e-040.2450image
chr11:66629799-66637364:+OVGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.0035e-040.2450image
chr11:66629799-66637364:+PAADGSVA_HALLMARK_MITOTIC_SPINDLEEER7.5829e-030.3563image
ENSG00000248643.5,RBM14-RBM4PAADGSVA_HALLMARK_MITOTIC_SPINDLEEAG7.5829e-030.3563image
chr11:66629799-66637364:+PRADGSVA_HALLMARK_PROTEIN_SECRETIONEER2.7799e-030.2777image
ENSG00000248643.5,RBM14-RBM4PRADGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3245e-030.2972image
ENSG00000248643.5,RBM14-RBM4READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG6.1371e-030.5325image
chr11:66629799-66637364:+READGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER6.1371e-030.5325image
chr11:66629799-66637364:+SARCGSVA_HALLMARK_HEME_METABOLISMEER1.9344e-030.3720image
ENSG00000248643.5,RBM14-RBM4SARCGSVA_HALLMARK_HEME_METABOLISMEAG1.9344e-030.3720image
chr11:66629799-66637364:+STADGSVA_HALLMARK_HYPOXIAEER3.6514e-100.3568image
ENSG00000248643.5,RBM14-RBM4STADGSVA_HALLMARK_HYPOXIAEAG4.3467e-100.3554image
ENSG00000248643.5,RBM14-RBM4TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG5.0478e-040.4536image
chr11:66629799-66637364:+TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEER5.0478e-040.4536image
ENSG00000248643.5,RBM14-RBM4THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG2.1741e-03-0.3882image
chr11:66629799-66637364:+THYMGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER2.1741e-03-0.3882image


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7. Enriched editing regions and drugs for RBM14-RBM4


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000248643.5,RBM14-RBM4BLCAABT.263EAG3.3361e-020.1540image
chr11:66629799-66637364:+BLCAABT.263EER3.3361e-020.1540image
chr11:66629799-66637364:+BRCAAZD6482EER1.3711e-02-0.1262image
ENSG00000248643.5,RBM14-RBM4BRCAAZD6482EAG1.6639e-02-0.1225image
chr11:66629799-66637364:+CESCErlotinibEER1.0263e-020.2070image
ENSG00000248643.5,RBM14-RBM4CESCErlotinibEAG1.0263e-020.2070image
chr11:66629799-66637364:+DLBCGDC.0449EER3.2143e-020.4058image
ENSG00000248643.5,RBM14-RBM4DLBCGDC.0449EAG3.2143e-020.4058image
ENSG00000248643.5,RBM14-RBM4ESCABexaroteneEAG3.4229e-04-0.2814image
chr11:66629799-66637364:+ESCABexaroteneEER3.8143e-04-0.2792image
ENSG00000248643.5,RBM14-RBM4GBMAZD6244EAG9.2883e-030.3253image
chr11:66629799-66637364:+GBMAZD6244EER9.2883e-030.3253image
ENSG00000248643.5,RBM14-RBM4HNSCGW843682XEAG2.4346e-040.3446image
chr11:66629799-66637364:+HNSCGW843682XEER2.4346e-040.3446image
ENSG00000248643.5,RBM14-RBM4KIRCFTI.277EAG1.4414e-02-0.2405image
chr11:66629799-66637364:+KIRCFTI.277EER1.4414e-02-0.2405image
chr11:66629799-66637364:+KIRPElesclomolEER3.9716e-020.2222image
ENSG00000248643.5,RBM14-RBM4KIRPElesclomolEAG4.1287e-020.2206image
ENSG00000248643.5,RBM14-RBM4LAMLBX.795EAG1.4046e-020.2002image
chr11:66629799-66637364:+LAMLBX.795EER2.0148e-020.1896image
ENSG00000248643.5,RBM14-RBM4LGGBryostatin.1EAG4.6486e-030.1915image
chr11:66629799-66637364:+LGGBryostatin.1EER6.8145e-030.1832image
ENSG00000248643.5,RBM14-RBM4LIHCMG.132EAG4.0594e-020.4041image
ENSG00000248643.5,RBM14-RBM4LUADKU.55933EAG2.0956e-02-0.1624image
chr11:66629799-66637364:+LUADKU.55933EER2.1118e-02-0.1622image
chr11:66629799-66637364:+LUSCBexaroteneEER4.8698e-05-0.3080image
ENSG00000248643.5,RBM14-RBM4LUSCBexaroteneEAG4.8698e-05-0.3080image
ENSG00000248643.5,RBM14-RBM4OVBMS.536924EAG1.5366e-03-0.2005image
chr11:66629799-66637364:+OVBMS.536924EER1.5358e-03-0.2005image
chr11:66629799-66637364:+PAADCI.1040EER8.5999e-030.3510image
ENSG00000248643.5,RBM14-RBM4PAADCI.1040EAG8.5999e-030.3510image
chr11:66629799-66637364:+PRADMethotrexateEER5.9698e-03-0.2571image
ENSG00000248643.5,RBM14-RBM4PRADMethotrexateEAG1.1996e-02-0.2356image
ENSG00000248643.5,RBM14-RBM4READJNK.9LEAG1.7348e-02-0.4715image
chr11:66629799-66637364:+READJNK.9LEER1.7348e-02-0.4715image
chr11:66629799-66637364:+SARCABT.263EER1.9311e-06-0.5442image
ENSG00000248643.5,RBM14-RBM4SARCABT.263EAG1.9311e-06-0.5442image
chr11:66629799-66637364:+STADAZ628EER4.5387e-05-0.2367image
ENSG00000248643.5,RBM14-RBM4STADAZ628EAG4.6498e-05-0.2364image
ENSG00000248643.5,RBM14-RBM4TGCTBAY.61.3606EAG4.0258e-03-0.3818image
chr11:66629799-66637364:+TGCTBAY.61.3606EER4.0258e-03-0.3818image
ENSG00000248643.5,RBM14-RBM4THCABI.D1870EAG5.0599e-030.2426image
chr11:66629799-66637364:+THCABI.D1870EER5.0599e-030.2426image
ENSG00000248643.5,RBM14-RBM4THYMJW.7.52.1EAG1.8667e-030.3935image
chr11:66629799-66637364:+THYMJW.7.52.1EER1.8667e-030.3935image
ENSG00000248643.5,RBM14-RBM4UCECCHIR.99021EAG3.9083e-03-0.4009image
chr11:66629799-66637364:+UCECCHIR.99021EER3.9083e-03-0.4009image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType