CAeditome Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF587B (ImmuneEditome ID:100293516)

1. Gene summary of enriched editing regions for ZNF587B

check button Gene summary
Gene informationGene symbol

ZNF587B

Gene ID

100293516

GeneSynonyms-
GeneCytomap

19q13.43

GeneTypeprotein-coding
GeneDescriptionzinc finger protein 587B
GeneModificationdate20230518
UniprotIDE7ETH6;A0A494C1I7;M0QY62;M0R1N2
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr19:57838022-57838543:+ENST00000442832.7ENSG00000269343.5ZNF587BintronicAluSg,AluScchr19:57838022-57838543:+.alignment
chr19:57838022-57838543:+ENST00000594328.1ENSG00000269343.5ZNF587BintronicAluSg,AluScchr19:57838022-57838543:+.alignment
chr19:57838022-57838543:+ENST00000594901.1ENSG00000269343.5ZNF587BintronicAluSg,AluScchr19:57838022-57838543:+.alignment
chr19:57842986-57846972:+ENST00000442832.7ENSG00000269343.5ZNF587Bexonic(TTGG)n,L1ME1,AluSz,AluSx4,AluJb,AluJr,AluSg7,AluSxchr19:57842986-57846972:+.alignment


Top

2. Tumor-specific enriched editing regions for ZNF587B


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr19:57842986-57846972:+KICHEER9.1990e-03image
ENSG00000269343.5,ZNF587BKICHEAG9.1990e-03image
chr19:57842986-57846972:+LIHCEER2.0347e-02image
ENSG00000269343.5,ZNF587BLIHCEAG2.0221e-02image
chr19:57842986-57846972:+PRADEER3.4146e-03image
ENSG00000269343.5,ZNF587BPRADEAG3.2599e-03image


Top

check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000269343.5,ZNF587BKIRPCliEAG4.9525e-022.0972e-020.1734image
chr19:57842986-57846972:+KIRPPathEER1.8428e-029.7661e-030.1704image
ENSG00000269343.5,ZNF587BTGCTPathEAG1.2992e-025.2011e-03-0.3058image
chr19:57842986-57846972:+TGCTPathEER1.4242e-025.7706e-03-0.3023image


Top

check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
chr19:57842986-57846972:+KIRCEER3.8911e-023.6583e-039.2620e+01image
ENSG00000269343.5,ZNF587BKIRCEAG3.8911e-023.5848e-039.3388e+01image

Top

3. Enriched editing regions and immune related genes for ZNF587B


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:57842986-57846972:+LIHCEERENSG00000269343,ZNF587B-0.48709.4510e-185.3675e-20-0.4589imageNNNAMacrophages_M0GSVA_HALLMARK_XENOBIOTIC_METABOLISM
chr19:57842986-57846972:+KICHEERENSG00000139842,CUL4A0.62531.3304e-022.0403e-080.6407imageNNCUL4AMonocytesGSVA_HALLMARK_PROTEIN_SECRETION
chr19:57842986-57846972:+KICHEERENSG00000142235,LMTK3-0.56362.0354e-027.1446e-06-0.5360imageNNNAGSVA_HALLMARK_MITOTIC_SPINDLE
chr19:57842986-57846972:+KICHEERENSG00000136100,VPS360.57632.5758e-022.3659e-080.6385imageNNNAMonocytesGSVA_HALLMARK_HEME_METABOLISM
chr19:57842986-57846972:+KICHEERENSG00000152484,USP120.56732.5938e-028.8147e-080.6178imageNNNAMonocytesGSVA_HALLMARK_HEME_METABOLISM
chr19:57842986-57846972:+KICHEERENSG00000185896,LAMP10.58172.5938e-024.3299e-050.4949imageNNLAMP1MonocytesGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
chr19:57842986-57846972:+KICHEERENSG00000102763,VWA80.57352.6627e-021.9917e-080.6410imageNNNAEosinophilsGSVA_HALLMARK_PROTEIN_SECRETION
chr19:57842986-57846972:+KICHEERENSG00000132964,CDK80.57172.6627e-022.4444e-060.5581imageNNNAMonocytesGSVA_HALLMARK_HEME_METABOLISM
chr19:57842986-57846972:+KICHEERENSG00000188811,NHLRC30.56352.8074e-024.3812e-040.4331imageNNNAMonocytesGSVA_HALLMARK_HEME_METABOLISM
chr19:57842986-57846972:+KICHEERENSG00000032742,IFT880.56502.8909e-026.3809e-050.4854imageNNIFT88MonocytesGSVA_HALLMARK_MITOTIC_SPINDLE

More results



Top

4. Enriched editing regions and immune related splicing for ZNF587B


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr19:57842986-57846972:+
ESCAEERIRENSG00000084693.11chr227067493:27069094:27069572:27069706-0.30053.7458e-028.4823e-07-0.4020imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr19:57842986-57846972:+
ESCAEERIRENSG00000084693.11chr227067493:27068744:27069047:27069094-0.28434.7839e-028.5422e-07-0.4088imageNNNAT_cells_CD4_memory_restingGSVA_HALLMARK_SPERMATOGENESIS
ENSG00000269343.5,ZNF587B
ESCAEAGIRENSG00000084693.11chr227067493:27069094:27069572:27069706-0.31143.0155e-028.1036e-07-0.4027imageNACIN1;ADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPL;HNRNPM;HNRNPU;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAT_cells_CD4_memory_restingGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING

More results



Top

5. Enriched editing regions and immune infiltration for ZNF587B


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr19:57842986-57846972:+ACCEERPlasma_cells3.5727e-020.2813image
ENSG00000269343.5,ZNF587BACCEAGPlasma_cells2.4792e-020.2998image
chr19:57842986-57846972:+BLCAEERMacrophages_M12.0242e-040.1869image
ENSG00000269343.5,ZNF587BBLCAEAGMacrophages_M11.4292e-040.1912image
chr19:57842986-57846972:+BRCAEERB_cells_naive8.4174e-03-0.0801image
ENSG00000269343.5,ZNF587BBRCAEAGB_cells_naive1.1616e-02-0.0767image
chr19:57842986-57846972:+CHOLEERT_cells_CD81.9024e-020.3945image
ENSG00000269343.5,ZNF587BCHOLEAGT_cells_CD81.8658e-020.3956image
chr19:57842986-57846972:+COADEERMacrophages_M01.2536e-020.1541image
ENSG00000269343.5,ZNF587BCOADEAGMacrophages_M01.8238e-020.1455image
chr19:57842986-57846972:+DLBCEERMonocytes1.0654e-030.4671image
ENSG00000269343.5,ZNF587BDLBCEAGMonocytes9.3704e-040.4716image
chr19:57842986-57846972:+ESCAEERMacrophages_M04.0288e-030.2255image
ENSG00000269343.5,ZNF587BESCAEAGMacrophages_M05.8156e-030.2165image
chr19:57842986-57846972:+HNSCEERNK_cells_resting1.4265e-020.1172image
ENSG00000269343.5,ZNF587BHNSCEAGNK_cells_resting1.4389e-020.1170image
chr19:57842986-57846972:+KICHEEREosinophils1.6585e-030.3914image
ENSG00000269343.5,ZNF587BKICHEAGEosinophils1.6585e-030.3914image
chr19:57842986-57846972:+KIRCEERNeutrophils3.4053e-020.1099image
ENSG00000269343.5,ZNF587BKIRCEAGNeutrophils3.6322e-020.1086image
chr19:57842986-57846972:+KIRPEERMacrophages_M12.1405e-040.2298image
ENSG00000269343.5,ZNF587BKIRPEAGMacrophages_M12.7310e-040.2256image
chr19:57842986-57846972:+LAMLEERT_cells_CD4_memory_resting1.3021e-02-0.2087image
ENSG00000269343.5,ZNF587BLAMLEAGT_cells_CD4_memory_resting1.6817e-02-0.1983image
chr19:57842986-57846972:+LGGEERMacrophages_M24.1029e-02-0.1173image
chr19:57842986-57846972:+LIHCEERB_cells_memory1.3807e-03-0.1687image
ENSG00000269343.5,ZNF587BLIHCEAGB_cells_memory1.3748e-03-0.1687image
chr19:57842986-57846972:+LUADEERT_cells_regulatory_(Tregs)1.4957e-03-0.1438image
ENSG00000269343.5,ZNF587BLUADEAGT_cells_regulatory_(Tregs)1.5135e-03-0.1437image
chr19:57842986-57846972:+LUSCEERNK_cells_resting1.7252e-020.1106image
ENSG00000269343.5,ZNF587BLUSCEAGNK_cells_resting1.6545e-020.1113image
chr19:57842986-57846972:+MESOEERMacrophages_M04.9557e-02-0.2246image
ENSG00000269343.5,ZNF587BMESOEAGMacrophages_M04.9557e-02-0.2246image
chr19:57838022-57838543:+OVEERT_cells_follicular_helper4.2403e-02-0.4009image
chr19:57842986-57846972:+OVEERMacrophages_M14.1102e-020.1280image
chr19:57842986-57846972:+PAADEERPlasma_cells4.6895e-02-0.1509image
ENSG00000269343.5,ZNF587BPAADEAGPlasma_cells4.4479e-02-0.1525image
chr19:57842986-57846972:+PCPGEERT_cells_gamma_delta1.3494e-020.1932image
ENSG00000269343.5,ZNF587BPCPGEAGT_cells_gamma_delta1.1665e-020.1971image
chr19:57842986-57846972:+PRADEERT_cells_CD4_memory_resting4.4896e-040.1565image
ENSG00000269343.5,ZNF587BPRADEAGT_cells_CD4_memory_resting3.3534e-040.1599image
chr19:57842986-57846972:+READEERMacrophages_M22.4029e-020.2405image
ENSG00000269343.5,ZNF587BREADEAGMacrophages_M22.3812e-020.2408image
chr19:57842986-57846972:+SARCEERMacrophages_M11.1440e-020.1836image
ENSG00000269343.5,ZNF587BSARCEAGMacrophages_M11.1984e-020.1820image
chr19:57842986-57846972:+STADEERMonocytes1.0581e-020.1363image
ENSG00000269343.5,ZNF587BSTADEAGMonocytes7.0543e-030.1430image
chr19:57842986-57846972:+TGCTEERMacrophages_M29.6336e-04-0.2618image
ENSG00000269343.5,ZNF587BTGCTEAGMacrophages_M29.7121e-04-0.2616image
chr19:57842986-57846972:+THCAEERT_cells_CD87.4910e-04-0.1518image
ENSG00000269343.5,ZNF587BTHCAEAGT_cells_CD87.8106e-04-0.1513image
chr19:57842986-57846972:+THYMEERT_cells_CD4_naive1.5047e-03-0.2914image
ENSG00000269343.5,ZNF587BTHYMEAGMacrophages_M12.2325e-030.2800image
chr19:57842986-57846972:+UCECEERNK_cells_resting3.0724e-02-0.1673image
ENSG00000269343.5,ZNF587BUCECEAGDendritic_cells_activated2.9699e-020.1673image
chr19:57842986-57846972:+UCSEERDendritic_cells_activated3.1738e-020.3138image
ENSG00000269343.5,ZNF587BUCSEAGDendritic_cells_activated3.1738e-020.3138image
chr19:57842986-57846972:+UVMEERT_cells_gamma_delta8.6974e-03-0.2971image
ENSG00000269343.5,ZNF587BUVMEAGT_cells_gamma_delta8.6974e-03-0.2971image


Top

6. Enriched editing regions and immune gene sets for ZNF587B


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


Top

check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
ENSG00000269343.5,ZNF587BTGCTEAG1.4464e-05-0.33962.2619e-04-0.29121.6302e-06-0.37296.3903e-03-0.2175image
chr19:57842986-57846972:+TGCTEER1.5352e-05-0.33862.3135e-04-0.29071.6304e-06-0.37296.2201e-03-0.2182image


Top

check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000269343.5,ZNF587BACCGSVA_HALLMARK_FATTY_ACID_METABOLISMEAG3.4976e-020.2824image
ENSG00000269343.5,ZNF587BBLCAGSVA_HALLMARK_HYPOXIAEAG8.7751e-120.3362image
chr19:57842986-57846972:+BLCAGSVA_HALLMARK_HYPOXIAEER5.8291e-120.3389image
ENSG00000269343.5,ZNF587BBRCAGSVA_HALLMARK_HYPOXIAEAG8.1320e-150.2332image
chr19:57842986-57846972:+BRCAGSVA_HALLMARK_HYPOXIAEER2.0764e-140.2297image
ENSG00000269343.5,ZNF587BCESCGSVA_HALLMARK_MYOGENESISEAG5.7554e-030.1638image
chr19:57842986-57846972:+CESCGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.4441e-030.1733image
ENSG00000269343.5,ZNF587BCHOLGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEAG4.0973e-030.4732image
chr19:57842986-57846972:+CHOLGSVA_HALLMARK_PI3K_AKT_MTOR_SIGNALINGEER4.3203e-030.4707image
chr19:57842986-57846972:+COADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEER2.9502e-060.2842image
ENSG00000269343.5,ZNF587BCOADGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG3.6121e-060.2812image
ENSG00000269343.5,ZNF587BESCAGSVA_HALLMARK_P53_PATHWAYEAG4.8861e-040.2717image
chr19:57842986-57846972:+ESCAGSVA_HALLMARK_P53_PATHWAYEER2.3510e-040.2860image
ENSG00000269343.5,ZNF587BGBMGSVA_HALLMARK_MYC_TARGETS_V1EAG1.4137e-02-0.2164image
chr19:57842986-57846972:+GBMGSVA_HALLMARK_MYC_TARGETS_V1EER1.1454e-02-0.2229image
chr19:57842986-57846972:+HNSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER3.0145e-130.3395image
ENSG00000269343.5,ZNF587BHNSCGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG3.2091e-130.3391image
ENSG00000269343.5,ZNF587BKICHGSVA_HALLMARK_HEME_METABOLISMEAG2.2595e-040.4520image
chr19:57842986-57846972:+KICHGSVA_HALLMARK_HEME_METABOLISMEER2.2595e-040.4520image
ENSG00000269343.5,ZNF587BKIRCGSVA_HALLMARK_KRAS_SIGNALING_UPEAG1.3656e-040.1965image
chr19:57842986-57846972:+KIRCGSVA_HALLMARK_KRAS_SIGNALING_UPEER1.7221e-040.1936image
chr19:57842986-57846972:+KIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEER2.8110e-03-0.1864image
ENSG00000269343.5,ZNF587BKIRPGSVA_HALLMARK_TGF_BETA_SIGNALINGEAG2.0261e-03-0.1920image
ENSG00000269343.5,ZNF587BLAMLGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEAG1.6362e-020.1991image
ENSG00000269343.5,ZNF587BLGGGSVA_HALLMARK_KRAS_SIGNALING_DNEAG7.1312e-070.2794image
chr19:57842986-57846972:+LGGGSVA_HALLMARK_KRAS_SIGNALING_DNEER8.0516e-070.2785image
chr19:57842986-57846972:+LIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER2.3583e-120.3598image
ENSG00000269343.5,ZNF587BLIHCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.2929e-120.3600image
ENSG00000269343.5,ZNF587BLUADGSVA_HALLMARK_APOPTOSISEAG2.2264e-070.2326image
chr19:57842986-57846972:+LUADGSVA_HALLMARK_APOPTOSISEER2.1224e-070.2329image
chr19:57842986-57846972:+LUSCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER3.1668e-030.1369image
ENSG00000269343.5,ZNF587BLUSCGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.6714e-030.1393image
chr19:57842986-57846972:+MESOGSVA_HALLMARK_UV_RESPONSE_DNEER2.1507e-030.3446image
ENSG00000269343.5,ZNF587BMESOGSVA_HALLMARK_UV_RESPONSE_DNEAG2.1507e-030.3446image
chr19:57842986-57846972:+OVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER1.0496e-030.2040image
ENSG00000269343.5,ZNF587BOVGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG9.4276e-030.1610image
chr19:57842986-57846972:+PAADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER1.6874e-020.1810image
ENSG00000269343.5,ZNF587BPAADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEAG1.7459e-020.1800image
ENSG00000269343.5,ZNF587BPCPGGSVA_HALLMARK_E2F_TARGETSEAG4.6082e-02-0.1565image
chr19:57842986-57846972:+PCPGGSVA_HALLMARK_MITOTIC_SPINDLEEER3.3145e-02-0.1670image
ENSG00000269343.5,ZNF587BPRADGSVA_HALLMARK_UV_RESPONSE_DNEAG3.7415e-060.2054image
chr19:57842986-57846972:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER2.4902e-050.1875image
ENSG00000269343.5,ZNF587BSKCMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG2.6159e-040.1720image
chr19:57842986-57846972:+SKCMGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.5997e-040.1721image
ENSG00000269343.5,ZNF587BSTADGSVA_HALLMARK_APOPTOSISEAG1.1273e-050.2310image
chr19:57842986-57846972:+STADGSVA_HALLMARK_APOPTOSISEER5.9144e-040.1825image
ENSG00000269343.5,ZNF587BTGCTGSVA_HALLMARK_GLYCOLYSISEAG3.9136e-06-0.3600image
chr19:57842986-57846972:+TGCTGSVA_HALLMARK_GLYCOLYSISEER3.9174e-06-0.3600image
chr19:57842986-57846972:+THCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER7.6130e-110.2885image
ENSG00000269343.5,ZNF587BTHCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG7.4202e-110.2886image
ENSG00000269343.5,ZNF587BTHYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG3.0689e-040.3279image
chr19:57842986-57846972:+THYMGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.3623e-040.3272image
chr19:57842986-57846972:+UCSGSVA_HALLMARK_KRAS_SIGNALING_DNEER2.5850e-030.4296image
ENSG00000269343.5,ZNF587BUCSGSVA_HALLMARK_KRAS_SIGNALING_DNEAG2.5850e-030.4296image


Top

7. Enriched editing regions and drugs for ZNF587B


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000269343.5,ZNF587BACCJNK.9LEAG4.6948e-020.2667image
ENSG00000269343.5,ZNF587BBLCAKIN001.135EAG5.5991e-10-0.3070image
chr19:57842986-57846972:+BLCAKIN001.135EER4.7360e-10-0.3082image
ENSG00000269343.5,ZNF587BBRCAAZD.0530EAG3.9701e-06-0.1400image
chr19:57842986-57846972:+BRCAAZD.0530EER4.8595e-06-0.1387image
ENSG00000269343.5,ZNF587BCESCAZD.0530EAG1.5511e-02-0.1438image
chr19:57842986-57846972:+CESCIPA.3EER3.2198e-020.1274image
ENSG00000269343.5,ZNF587BCHOLCGP.082996EAG2.8796e-03-0.4889image
chr19:57842986-57846972:+CHOLCGP.082996EER2.8295e-03-0.4897image
chr19:57842986-57846972:+COADAP.24534EER4.7458e-04-0.2144image
ENSG00000269343.5,ZNF587BCOADAP.24534EAG3.8104e-04-0.2175image
ENSG00000269343.5,ZNF587BDLBCElesclomolEAG4.9531e-030.4074image
chr19:57842986-57846972:+DLBCElesclomolEER4.8169e-030.4086image
ENSG00000269343.5,ZNF587BESCAKIN001.135EAG2.4995e-05-0.3256image
chr19:57842986-57846972:+ESCAKIN001.135EER1.6374e-05-0.3325image
ENSG00000269343.5,ZNF587BGBMDocetaxelEAG1.4570e-030.2785image
chr19:57842986-57846972:+GBMDocetaxelEER1.3042e-030.2812image
ENSG00000269343.5,ZNF587BHNSCLFM.A13EAG8.8686e-08-0.2524image
chr19:57842986-57846972:+HNSCLFM.A13EER8.5553e-08-0.2527image
chr19:57842986-57846972:+KICHA.443654EER1.9218e-030.3864image
ENSG00000269343.5,ZNF587BKICHA.443654EAG1.9218e-030.3864image
ENSG00000269343.5,ZNF587BKIRCBI.2536EAG1.2945e-030.1662image
chr19:57842986-57846972:+KIRCBI.2536EER7.4037e-040.1742image
ENSG00000269343.5,ZNF587BKIRPGSK.650394EAG1.2075e-040.2380image
chr19:57842986-57846972:+KIRPGSK.650394EER1.6017e-040.2342image
ENSG00000269343.5,ZNF587BLAMLCGP.60474EAG1.4463e-02-0.2027image
chr19:57842986-57846972:+LAMLCGP.60474EER1.3506e-02-0.2076image
ENSG00000269343.5,ZNF587BLGGGemcitabineEAG9.5323e-060.2505image
chr19:57842986-57846972:+LGGGemcitabineEER1.0420e-050.2498image
chr19:57842986-57846972:+LIHCGemcitabineEER2.8016e-080.2886image
ENSG00000269343.5,ZNF587BLIHCGemcitabineEAG2.8525e-080.2885image
chr19:57842986-57846972:+LUADGemcitabineEER1.1245e-06-0.2189image
ENSG00000269343.5,ZNF587BLUADGemcitabineEAG1.2528e-06-0.2180image
ENSG00000269343.5,ZNF587BLUSCEmbelinEAG3.7139e-040.1647image
chr19:57842986-57846972:+LUSCEmbelinEER4.3200e-040.1629image
ENSG00000269343.5,ZNF587BMESOAKT.inhibitor.VIIIEAG2.0213e-03-0.3465image
chr19:57842986-57846972:+MESOAKT.inhibitor.VIIIEER2.0213e-03-0.3465image
chr19:57838022-57838543:+OVAZD8055EER8.8150e-03-0.5030image
chr19:57842986-57846972:+OVAZD.2281EER1.7511e-02-0.1490image
ENSG00000269343.5,ZNF587BOVAZD.2281EAG2.3737e-02-0.1408image
ENSG00000269343.5,ZNF587BPAADBleomycinEAG1.9740e-040.2786image
chr19:57842986-57846972:+PAADBleomycinEER2.0292e-040.2781image
chr19:57842986-57846972:+PCPGIPA.3EER9.6589e-040.2561image
ENSG00000269343.5,ZNF587BPCPGIPA.3EAG1.0004e-030.2554image
ENSG00000269343.5,ZNF587BPRADCEP.701EAG2.5270e-080.2462image
chr19:57842986-57846972:+PRADCEP.701EER1.7687e-090.2652image
ENSG00000269343.5,ZNF587BREADEtoposideEAG2.9143e-020.2327image
chr19:57842986-57846972:+READEtoposideEER2.9358e-020.2324image
ENSG00000269343.5,ZNF587BSARCGW843682XEAG5.4616e-03-0.2008image
chr19:57842986-57846972:+SARCGW843682XEER3.7178e-03-0.2101image
ENSG00000269343.5,ZNF587BSKCMAS601245EAG3.2588e-04-0.1694image
chr19:57842986-57846972:+SKCMAS601245EER3.2715e-04-0.1694image
chr19:57842986-57846972:+STADKU.55933EER3.6283e-05-0.2189image
chr19:57838022-57838543:+STADGDC.0449EER4.8436e-03-0.3849image
ENSG00000269343.5,ZNF587BSTADKU.55933EAG4.5680e-05-0.2152image
chr19:57842986-57846972:+TGCTDocetaxelEER4.6502e-060.3574image
ENSG00000269343.5,ZNF587BTGCTDocetaxelEAG4.4215e-060.3582image
ENSG00000269343.5,ZNF587BTHCAAxitinibEAG8.1524e-080.2394image
chr19:57842986-57846972:+THCAAxitinibEER7.5558e-080.2400image
chr19:57842986-57846972:+THYMABT.263EER7.6465e-060.4022image
ENSG00000269343.5,ZNF587BTHYMABT.263EAG1.0117e-050.3956image
chr19:57842986-57846972:+UCECA.770041EER6.9961e-05-0.3027image
ENSG00000269343.5,ZNF587BUCECA.770041EAG2.9046e-04-0.2754image
ENSG00000269343.5,ZNF587BUCSBosutinibEAG2.7793e-020.3210image
chr19:57842986-57846972:+UCSBosutinibEER2.7793e-020.3210image
ENSG00000269343.5,ZNF587BUVMAZD8055EAG6.8343e-040.3787image
chr19:57842986-57846972:+UVMAZD8055EER6.8343e-040.3787image


Top

check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType