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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: KCTD21-AS1 (ImmuneEditome ID:100289388)

1. Gene summary of enriched editing regions for KCTD21-AS1

check button Gene summary
Gene informationGene symbol

KCTD21-AS1

Gene ID

100289388

GeneSynonyms-
GeneCytomap

11q14.1

GeneTypencRNA
GeneDescription-
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr11:78141209-78143022:+ENST00000500113.1ENSG00000246174.6KCTD21-AS1ncRNA_exonicL2b,(TGA)n,MLT1D,AluSx1,AluJo,AluSg7chr11:78141209-78143022:+.alignment
chr11:78141209-78143022:+ENST00000527321.1ENSG00000246174.6KCTD21-AS1ncRNA_exonicL2b,(TGA)n,MLT1D,AluSx1,AluJo,AluSg7chr11:78141209-78143022:+.alignment
chr11:78141209-78143022:+ENST00000530261.1ENSG00000246174.6KCTD21-AS1ncRNA_exonicL2b,(TGA)n,MLT1D,AluSx1,AluJo,AluSg7chr11:78141209-78143022:+.alignment
chr11:78141209-78143022:+ENST00000532831.1ENSG00000246174.6KCTD21-AS1ncRNA_exonicL2b,(TGA)n,MLT1D,AluSx1,AluJo,AluSg7chr11:78141209-78143022:+.alignment
chr11:78152331-78152786:+ENST00000523626.5ENSG00000246174.6KCTD21-AS1ncRNA_intronicAluSz,MIR,AluSx1,ERVL-B4-intchr11:78152331-78152786:+.alignment
chr11:78152331-78152786:+ENST00000530261.1ENSG00000246174.6KCTD21-AS1ncRNA_intronicAluSz,MIR,AluSx1,ERVL-B4-intchr11:78152331-78152786:+.alignment
chr11:78154889-78155790:+ENST00000523626.5ENSG00000246174.6KCTD21-AS1ncRNA_intronicMIRb,AluSx3,L1ME4b,AluJb,MLT2C1chr11:78154889-78155790:+.alignment
chr11:78154889-78155790:+ENST00000530261.1ENSG00000246174.6KCTD21-AS1ncRNA_intronicMIRb,AluSx3,L1ME4b,AluJb,MLT2C1chr11:78154889-78155790:+.alignment


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2. Tumor-specific enriched editing regions for KCTD21-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000246174.6,KCTD21-AS1UCECCliEAG2.8314e-032.0420e-030.2788image
chr11:78141209-78143022:+UCECCliEER1.7533e-031.0911e-030.2958image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for KCTD21-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for KCTD21-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for KCTD21-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr11:78141209-78143022:+BLCAEERT_cells_CD4_memory_activated2.4737e-030.3900image
ENSG00000246174.6,KCTD21-AS1BLCAEAGT_cells_CD4_memory_activated2.4737e-030.3900image
chr11:78141209-78143022:+BRCAEERDendritic_cells_resting1.0981e-020.1708image
ENSG00000246174.6,KCTD21-AS1BRCAEAGDendritic_cells_resting1.1197e-020.1703image
chr11:78141209-78143022:+ESCAEEREosinophils4.8796e-030.5659image
ENSG00000246174.6,KCTD21-AS1ESCAEAGEosinophils4.8796e-030.5659image
ENSG00000246174.6,KCTD21-AS1GBMEAGT_cells_CD4_memory_activated2.3069e-020.4527image
ENSG00000246174.6,KCTD21-AS1HNSCEAGB_cells_memory3.7762e-02-0.3632image
ENSG00000246174.6,KCTD21-AS1KIRPEAGNK_cells_resting3.5431e-030.5324image
chr11:78141209-78143022:+LUSCEERMonocytes8.1316e-03-0.3034image
ENSG00000246174.6,KCTD21-AS1LUSCEAGMonocytes8.0893e-03-0.3036image
chr11:78141209-78143022:+OVEERMacrophages_M02.5774e-03-0.2284image
ENSG00000246174.6,KCTD21-AS1OVEAGMacrophages_M02.1806e-03-0.2322image
chr11:78141209-78143022:+SARCEERDendritic_cells_activated1.8888e-060.6872image
ENSG00000246174.6,KCTD21-AS1SARCEAGDendritic_cells_activated1.8888e-060.6872image
ENSG00000246174.6,KCTD21-AS1STADEAGB_cells_memory2.9943e-020.3314image
chr11:78141209-78143022:+THCAEERMacrophages_M12.8846e-020.1697image
ENSG00000246174.6,KCTD21-AS1THCAEAGMacrophages_M12.8846e-020.1697image
ENSG00000246174.6,KCTD21-AS1THYMEAGMacrophages_M07.9128e-030.3751image
chr11:78141209-78143022:+UCECEERT_cells_gamma_delta1.7975e-020.2708image
ENSG00000246174.6,KCTD21-AS1UCECEAGT_cells_gamma_delta2.9493e-020.2482image
ENSG00000246174.6,KCTD21-AS1UCSEAGEosinophils6.8469e-030.4831image
ENSG00000246174.6,KCTD21-AS1UVMEAGT_cells_CD83.2965e-02-0.3721image


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6. Enriched editing regions and immune gene sets for KCTD21-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr11:78141209-78143022:+BLCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEER1.0582e-030.4191image
ENSG00000246174.6,KCTD21-AS1BLCAGSVA_HALLMARK_IL2_STAT5_SIGNALINGEAG1.0582e-030.4191image
ENSG00000246174.6,KCTD21-AS1BRCAGSVA_HALLMARK_UV_RESPONSE_DNEAG7.4753e-060.2962image
chr11:78141209-78143022:+BRCAGSVA_HALLMARK_UV_RESPONSE_DNEER7.6881e-060.2958image
chr11:78141209-78143022:+CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEER3.1615e-030.4984image
ENSG00000246174.6,KCTD21-AS1CESCGSVA_HALLMARK_INTERFERON_GAMMA_RESPONSEEAG3.1615e-030.4984image
chr11:78141209-78143022:+ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEER9.7912e-030.5269image
ENSG00000246174.6,KCTD21-AS1ESCAGSVA_HALLMARK_MITOTIC_SPINDLEEAG9.7912e-030.5269image
ENSG00000246174.6,KCTD21-AS1GBMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG1.0259e-020.5037image
ENSG00000246174.6,KCTD21-AS1HNSCGSVA_HALLMARK_COAGULATIONEAG1.0032e-020.4419image
ENSG00000246174.6,KCTD21-AS1KIRPGSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATIONEAG3.8949e-02-0.3923image
ENSG00000246174.6,KCTD21-AS1LGGGSVA_HALLMARK_UV_RESPONSE_DNEAG2.1560e-030.5382image
ENSG00000246174.6,KCTD21-AS1LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEAG2.2709e-020.3318image
chr11:78141209-78143022:+LIHCGSVA_HALLMARK_PROTEIN_SECRETIONEER2.2709e-020.3318image
ENSG00000246174.6,KCTD21-AS1LUADGSVA_HALLMARK_NOTCH_SIGNALINGEAG3.0846e-020.3655image
chr11:78141209-78143022:+LUADGSVA_HALLMARK_NOTCH_SIGNALINGEER3.0846e-020.3655image
chr11:78141209-78143022:+LUSCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEER2.2632e-030.3474image
ENSG00000246174.6,KCTD21-AS1LUSCGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.2585e-030.3474image
ENSG00000246174.6,KCTD21-AS1OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.2962e-030.2310image
chr11:78141209-78143022:+OVGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER1.9818e-030.2342image
ENSG00000246174.6,KCTD21-AS1PRADGSVA_HALLMARK_G2M_CHECKPOINTEAG2.0590e-030.3933image
chr11:78141209-78143022:+PRADGSVA_HALLMARK_G2M_CHECKPOINTEER2.0590e-030.3933image
chr11:78141209-78143022:+SARCGSVA_HALLMARK_E2F_TARGETSEER9.5261e-03-0.4153image
ENSG00000246174.6,KCTD21-AS1SARCGSVA_HALLMARK_E2F_TARGETSEAG9.5261e-03-0.4153image
chr11:78141209-78143022:+SKCMGSVA_HALLMARK_MYC_TARGETS_V1EER1.5582e-02-0.2529image
ENSG00000246174.6,KCTD21-AS1SKCMGSVA_HALLMARK_MYC_TARGETS_V1EAG1.6022e-02-0.2519image
ENSG00000246174.6,KCTD21-AS1STADGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG5.9923e-030.4124image
chr11:78141209-78143022:+STADGSVA_HALLMARK_APICAL_SURFACEEER8.6082e-040.5062image
ENSG00000246174.6,KCTD21-AS1THCAGSVA_HALLMARK_UV_RESPONSE_DNEAG4.3117e-040.2702image
chr11:78141209-78143022:+THCAGSVA_HALLMARK_UV_RESPONSE_DNEER4.3117e-040.2702image
ENSG00000246174.6,KCTD21-AS1THYMGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG2.9211e-030.4164image
chr11:78141209-78143022:+UCECGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.6269e-020.2549image
ENSG00000246174.6,KCTD21-AS1UCECGSVA_HALLMARK_HEDGEHOG_SIGNALINGEAG1.8694e-020.2675image
ENSG00000246174.6,KCTD21-AS1UCSGSVA_HALLMARK_IL6_JAK_STAT3_SIGNALINGEAG2.2399e-020.4155image


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7. Enriched editing regions and drugs for KCTD21-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000246174.6,KCTD21-AS1BLCAAZD6482EAG7.8938e-03-0.3455image
chr11:78141209-78143022:+BLCAAZD6482EER7.8938e-03-0.3455image
ENSG00000246174.6,KCTD21-AS1BRCALFM.A13EAG3.5925e-04-0.2379image
chr11:78141209-78143022:+BRCALFM.A13EER3.4674e-04-0.2385image
chr11:78141209-78143022:+CESCBMS.754807EER1.6355e-020.4149image
ENSG00000246174.6,KCTD21-AS1CESCBMS.754807EAG1.6355e-020.4149image
ENSG00000246174.6,KCTD21-AS1ESCAAMG.706EAG2.2273e-020.4741image
chr11:78141209-78143022:+ESCAAMG.706EER2.2273e-020.4741image
ENSG00000246174.6,KCTD21-AS1GBMCyclopamineEAG9.1382e-04-0.6215image
ENSG00000246174.6,KCTD21-AS1HNSCAZD8055EAG1.5946e-020.4164image
ENSG00000246174.6,KCTD21-AS1KIRPCMKEAG5.9652e-030.5064image
ENSG00000246174.6,KCTD21-AS1LGGBX.795EAG1.0842e-02-0.4584image
chr11:78141209-78143022:+LIHCGNF.2EER1.0429e-020.3741image
ENSG00000246174.6,KCTD21-AS1LIHCGNF.2EAG1.0429e-020.3741image
chr11:78141209-78143022:+LUSCBMS.708163EER7.7662e-03-0.3052image
ENSG00000246174.6,KCTD21-AS1LUSCBMS.708163EAG7.7425e-03-0.3053image
ENSG00000246174.6,KCTD21-AS1PRADDasatinibEAG2.2671e-020.3069image
chr11:78141209-78143022:+PRADDasatinibEER2.2671e-020.3069image
chr11:78141209-78143022:+SARCGW.441756EER3.3545e-02-0.3456image
ENSG00000246174.6,KCTD21-AS1SARCGW.441756EAG3.3545e-02-0.3456image
chr11:78141209-78143022:+SKCMGW.441756EER7.1614e-030.2801image
ENSG00000246174.6,KCTD21-AS1SKCMGW.441756EAG7.2771e-030.2796image
ENSG00000246174.6,KCTD21-AS1STADAP.24534EAG1.1037e-04-0.5555image
chr11:78141209-78143022:+STADAP.24534EER3.7652e-03-0.4478image
ENSG00000246174.6,KCTD21-AS1THCAAP.24534EAG5.5212e-04-0.2653image
chr11:78141209-78143022:+THCAAP.24534EER5.5212e-04-0.2653image
ENSG00000246174.6,KCTD21-AS1THYMFTI.277EAG3.3364e-02-0.3046image
chr11:78141209-78143022:+UCECElesclomolEER1.0396e-020.2923image
ENSG00000246174.6,KCTD21-AS1UCECElesclomolEAG1.4576e-020.2774image
ENSG00000246174.6,KCTD21-AS1UVMAZD7762EAG9.2535e-030.4462image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType