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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: ZNF37BP (ImmuneEditome ID:100129482)

1. Gene summary of enriched editing regions for ZNF37BP

check button Gene summary
Gene informationGene symbol

ZNF37BP

Gene ID

100129482

GeneSynonymsKOX21|ZNF37B
GeneCytomap

10q11.21

GeneTypepseudo
GeneDescriptionzinc finger protein 37b (KOX 21)
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr10:42515982-42516283:-ENST00000452075.6ENSG00000234420.6ZNF37BPncRNA_exonicAluJbchr10:42515982-42516283:-.alignment
chr10:42517841-42518872:-ENST00000452075.6ENSG00000234420.6ZNF37BPncRNA_exonicAluYc,AluSxchr10:42517841-42518872:-.alignment


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2. Tumor-specific enriched editing regions for ZNF37BP


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr10:42515982-42516283:-BRCAEER4.5976e-04image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot
ENSG00000234420.6,ZNF37BPCOADPathEAG5.7746e-033.0310e-020.2394image


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot
ENSG00000234420.6,ZNF37BPHNSCEAG3.4187e-021.6058e-021.6707e+04image
chr10:42517841-42518872:-LUSCEER3.6943e-021.6812e-025.2529e-02image

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3. Enriched editing regions and immune related genes for ZNF37BP


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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4. Enriched editing regions and immune related splicing for ZNF37BP


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark

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5. Enriched editing regions and immune infiltration for ZNF37BP


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
ENSG00000234420.6,ZNF37BPBLCAEAGMacrophages_M01.9461e-020.2501image
chr10:42515982-42516283:-BRCAEERT_cells_CD4_naive2.7398e-030.1394image
ENSG00000234420.6,ZNF37BPBRCAEAGT_cells_CD4_naive3.2587e-020.0894image
ENSG00000234420.6,ZNF37BPCESCEAGNeutrophils1.1703e-030.3523image
chr10:42517841-42518872:-COADEERNK_cells_resting2.4968e-03-0.4069image
ENSG00000234420.6,ZNF37BPCOADEAGT_cells_CD4_memory_activated3.6844e-03-0.3292image
chr10:42517841-42518872:-ESCAEEREosinophils4.4176e-020.2271image
chr10:42517841-42518872:-HNSCEERNK_cells_activated4.6237e-020.3667image
ENSG00000234420.6,ZNF37BPHNSCEAGPlasma_cells4.8262e-020.3363image
ENSG00000234420.6,ZNF37BPLAMLEAGT_cells_CD4_naive3.2593e-02-0.2150image
chr10:42517841-42518872:-LGGEERDendritic_cells_activated1.5488e-030.1741image
ENSG00000234420.6,ZNF37BPLGGEAGT_cells_regulatory_(Tregs)4.3357e-030.1404image
ENSG00000234420.6,ZNF37BPLUADEAGNK_cells_resting1.4815e-020.2248image
chr10:42517841-42518872:-LUSCEERMacrophages_M13.3055e-02-0.2498image
chr10:42517841-42518872:-PCPGEERMacrophages_M22.4120e-03-0.3110image
ENSG00000234420.6,ZNF37BPPCPGEAGMacrophages_M22.4596e-02-0.2018image
ENSG00000234420.6,ZNF37BPPRADEAGT_cells_CD89.0576e-03-0.2255image
chr10:42517841-42518872:-SARCEERPlasma_cells3.3558e-020.3828image
chr10:42517841-42518872:-SKCMEERB_cells_memory3.3117e-020.1870image
ENSG00000234420.6,ZNF37BPSKCMEAGB_cells_memory8.5865e-030.2046image
chr10:42517841-42518872:-STADEERT_cells_CD81.4299e-020.1854image
ENSG00000234420.6,ZNF37BPSTADEAGT_cells_CD4_memory_activated9.8352e-030.1822image
ENSG00000234420.6,ZNF37BPUCECEAGMacrophages_M12.8909e-03-0.4341image


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6. Enriched editing regions and immune gene sets for ZNF37BP


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot
chr10:42515982-42516283:-BRCAEER9.4925e-040.15365.7739e-030.12854.5140e-040.16293.7947e-040.1650image


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
ENSG00000234420.6,ZNF37BPBLCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG1.2869e-020.2657image
ENSG00000234420.6,ZNF37BPBRCAGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG4.4870e-030.1188image
chr10:42517841-42518872:-BRCAGSVA_HALLMARK_FATTY_ACID_METABOLISMEER3.0294e-030.1384image
chr10:42515982-42516283:-BRCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.2260e-100.2942image
ENSG00000234420.6,ZNF37BPCESCGSVA_HALLMARK_P53_PATHWAYEAG1.2816e-02-0.2738image
ENSG00000234420.6,ZNF37BPCOADGSVA_HALLMARK_SPERMATOGENESISEAG4.9707e-02-0.2259image
chr10:42517841-42518872:-COADGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER3.4195e-020.2915image
chr10:42515982-42516283:-ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER1.0536e-020.2761image
ENSG00000234420.6,ZNF37BPESCAGSVA_HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITIONEAG8.0132e-03-0.2638image
ENSG00000234420.6,ZNF37BPGBMGSVA_HALLMARK_UV_RESPONSE_DNEAG8.2001e-030.3329image
chr10:42517841-42518872:-GBMGSVA_HALLMARK_UV_RESPONSE_DNEER1.3517e-020.4025image
chr10:42517841-42518872:-HNSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER2.8075e-02-0.4010image
ENSG00000234420.6,ZNF37BPKIRPGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG3.3431e-02-0.2564image
ENSG00000234420.6,ZNF37BPLGGGSVA_HALLMARK_XENOBIOTIC_METABOLISMEAG6.7067e-050.1953image
chr10:42517841-42518872:-LGGGSVA_HALLMARK_HEDGEHOG_SIGNALINGEER2.0852e-04-0.2034image
ENSG00000234420.6,ZNF37BPLUADGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG1.4194e-03-0.2917image
chr10:42517841-42518872:-LUADGSVA_HALLMARK_APICAL_SURFACEEER1.7251e-04-0.4232image
chr10:42517841-42518872:-OVGSVA_HALLMARK_MITOTIC_SPINDLEEER2.3886e-02-0.2193image
ENSG00000234420.6,ZNF37BPPAADGSVA_HALLMARK_APICAL_JUNCTIONEAG2.1368e-020.3722image
ENSG00000234420.6,ZNF37BPPCPGGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG2.6103e-02-0.1998image
chr10:42517841-42518872:-PCPGGSVA_HALLMARK_PANCREAS_BETA_CELLSEER3.9175e-020.2143image
ENSG00000234420.6,ZNF37BPPRADGSVA_HALLMARK_MYOGENESISEAG3.8933e-020.1793image
ENSG00000234420.6,ZNF37BPREADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.2844e-020.5213image
chr10:42517841-42518872:-SARCGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER3.6329e-040.5997image
ENSG00000234420.6,ZNF37BPSARCGSVA_HALLMARK_APICAL_SURFACEEAG3.5367e-040.4532image
chr10:42517841-42518872:-SKCMGSVA_HALLMARK_KRAS_SIGNALING_DNEER1.7507e-020.2081image
ENSG00000234420.6,ZNF37BPSKCMGSVA_HALLMARK_APICAL_SURFACEEAG2.9581e-020.1700image
chr10:42517841-42518872:-STADGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER3.2964e-02-0.1618image
ENSG00000234420.6,ZNF37BPTHCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEAG2.4544e-030.2665image
ENSG00000234420.6,ZNF37BPTHYMGSVA_HALLMARK_HYPOXIAEAG9.5557e-040.4912image
ENSG00000234420.6,ZNF37BPUCECGSVA_HALLMARK_ALLOGRAFT_REJECTIONEAG1.1576e-03-0.4689image


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7. Enriched editing regions and drugs for ZNF37BP


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000234420.6,ZNF37BPBLCAAS601245EAG1.8472e-020.2521image
chr10:42517841-42518872:-BRCAAZ628EER4.5738e-03-0.1324image
ENSG00000234420.6,ZNF37BPBRCAAZ628EAG1.5387e-02-0.1014image
chr10:42515982-42516283:-BRCAA.770041EER6.1819e-05-0.1861image
ENSG00000234420.6,ZNF37BPCESCLapatinibEAG9.3714e-040.3587image
chr10:42517841-42518872:-COADDasatinibEER8.6634e-03-0.3571image
ENSG00000234420.6,ZNF37BPESCAAMG.706EAG1.8474e-030.3076image
chr10:42515982-42516283:-ESCAMG.132EER1.6059e-03-0.3371image
chr10:42517841-42518872:-ESCAGW.441756EER2.9498e-020.2451image
chr10:42517841-42518872:-GBMCyclopamineEER4.5107e-02-0.3314image
ENSG00000234420.6,ZNF37BPHNSCGSK.650394EAG6.8795e-030.4486image
chr10:42517841-42518872:-HNSCBryostatin.1EER2.4078e-04-0.6223image
ENSG00000234420.6,ZNF37BPKIRPCI.1040EAG9.5592e-030.3099image
ENSG00000234420.6,ZNF37BPLAMLFTI.277EAG4.3563e-020.2033image
ENSG00000234420.6,ZNF37BPLGGMetforminEAG1.1499e-10-0.3110image
chr10:42517841-42518872:-LGGMetforminEER2.3441e-06-0.2573image
ENSG00000234420.6,ZNF37BPLUADCyclopamineEAG2.0635e-020.2138image
chr10:42517841-42518872:-LUADABT.888EER8.9646e-03-0.3018image
chr10:42517841-42518872:-LUSCAxitinibEER4.3912e-03-0.3297image
ENSG00000234420.6,ZNF37BPLUSCAxitinibEAG6.3937e-05-0.3624image
ENSG00000234420.6,ZNF37BPMESOAMG.706EAG3.9010e-03-0.5110image
ENSG00000234420.6,ZNF37BPOVBMS.509744EAG6.7021e-03-0.2220image
chr10:42517841-42518872:-OVGefitinibEER5.0277e-03-0.2706image
ENSG00000234420.6,ZNF37BPPCPGAICAREAG5.9034e-030.2459image
chr10:42517841-42518872:-PCPGCisplatinEER4.8250e-040.3549image
ENSG00000234420.6,ZNF37BPPRADImatinibEAG3.6153e-02-0.1819image
ENSG00000234420.6,ZNF37BPREADCCT007093EAG3.8824e-02-0.4432image
chr10:42517841-42518872:-SARCDMOGEER4.5890e-03-0.4955image
ENSG00000234420.6,ZNF37BPSARCBMS.536924EAG2.1971e-04-0.4670image
chr10:42517841-42518872:-SKCMAZD7762EER5.5958e-03-0.2426image
ENSG00000234420.6,ZNF37BPSKCMAZD7762EAG4.3469e-03-0.2223image
ENSG00000234420.6,ZNF37BPSTADMG.132EAG1.2730e-02-0.1759image
chr10:42517841-42518872:-STADMG.132EER7.8108e-03-0.2010image
ENSG00000234420.6,ZNF37BPTGCTJW.7.52.1EAG1.9749e-020.3923image
ENSG00000234420.6,ZNF37BPTHCAMetforminEAG1.2716e-030.2829image
ENSG00000234420.6,ZNF37BPTHYMDoxorubicinEAG3.4972e-020.3263image
ENSG00000234420.6,ZNF37BPUCECGefitinibEAG2.7926e-020.3278image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType