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Center for Computational Systems Medicine
Soverview

1. Gene summary of enriched editing regions

Soverview

2. Tumor-specific enriched editing regions

Comparison of enriched editing regions between tumor and normal.

Correlation of enriched editing regions with tumor stages.

Associations of enriched editing regions with cancer survival.

Soverview

3. Enriched editing regions and immune related genes

Soverview

4. Enriched editing regions and immune related splicing

Soverview

5. Enriched editing regions and immune infiltration

Soverview

6. Enriched editing regions and immune gene sets

Correlation of enriched editing regions with epithelial-mesenchymal transition.

Correlations of enriched editing regions with hypoxic.

Associations of enriched editing regions with hallmark gene sets from MSigDB.

Soverview

7. Enriched editing regions and drugs

Correlations between enriched editing regions and drug sensitivity.

Enriched editing regions targeted by drugs from DrugBank database.

Editing gene: GABPB1-AS1 (ImmuneEditome ID:100129387)

1. Gene summary of enriched editing regions for GABPB1-AS1

check button Gene summary
Gene informationGene symbol

GABPB1-AS1

Gene ID

100129387

GeneSynonyms-
GeneCytomap

15q21.2

GeneTypencRNA
GeneDescriptionGABPB1 antisense RNA 1 (non-protein coding)
GeneModificationdate20230329
UniprotID.
PubMed ID

check buttonUCSC image.
all structure

check buttonLocations of each EERs.
EERENSTENSGGeneNameRegionRepeatdsRNA structure
chr15:50357390-50358295:+ENST00000499624.3ENSG00000244879.4GABPB1-AS1ncRNA_exonicAluY,L2a,AluSxchr15:50357390-50358295:+.alignment
chr15:50360573-50361247:+ENST00000499624.3ENSG00000244879.4GABPB1-AS1ncRNA_exonicAluSz,AluJb,L1ME3Bchr15:50360573-50361247:+.alignment
chr15:50363380-50370828:+ENST00000499624.3ENSG00000244879.4GABPB1-AS1ncRNA_exonicAluJo,AluSx,AluSz6,AluJb,AluJr,AluSq2,AluSg,MLT1A,AluSz,AluSx1,MER113,MIRchr15:50363380-50370828:+.alignment
chr15:50363380-50370828:+ENST00000558593.1ENSG00000244879.4GABPB1-AS1ncRNA_exonicAluJo,AluSx,AluSz6,AluJb,AluJr,AluSq2,AluSg,MLT1A,AluSz,AluSx1,MER113,MIRchr15:50363380-50370828:+.alignment


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2. Tumor-specific enriched editing regions for GABPB1-AS1


all structure

check buttonComparison of enriched editing regions between tumor and normal.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypePBoxplot
chr15:50363380-50370828:+THCAEER3.8791e-02image
ENSG00000244879.4,GABPB1-AS1THCAEAG3.4026e-02image


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check buttonCorrelation of enriched editing regions with tumor stages.
* AnovaP<0.05, Pearson P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes, Path: Pathological stage, Cli: Clinical stage.
* Only shows the most significant correlation result of EERs/EAGs with either pathological stage or clinical stage according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeStageTypeAnovaPPRBoxplot


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check button Associations of enriched editing regions with cancer survival.
* Pkm<0.05 and Pcox<0.05.
* EER: enriched editing region, EAG: EER-associated genes.
ID_eventscancerTypeIDPkmPcox_continuousHR_continuousKMPlot

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3. Enriched editing regions and immune related genes for GABPB1-AS1


all structure

check button Enriched editing regions and immune related genes.
* First, the associations between enriched editing regions and genes were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the gene relationships with immune were tested by three analyses: whether the gene is an immune gene (InnateDB、Immport、Immunome、Immunogenetic Related Information Source (IRIS)), whether the gene is associated with immune infiltration and whether the gene is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of genes with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeGenebetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:50360573-50361247:+ESCAEERENSG00000188015,S100A30.38302.8615e-039.0789e-110.5263imageNEIF4A3NAT_cells_CD4_memory_restingGSVA_HALLMARK_BILE_ACID_METABOLISM
chr15:50360573-50361247:+ESCAEERENSG00000242147,RP13-463N16.60.36065.6848e-033.9817e-070.4243imageNEIF4A3NAMacrophages_M0GSVA_HALLMARK_HYPOXIA
chr15:50360573-50361247:+ESCAEERENSG00000174132,FAM174A0.36396.2060e-037.1185e-090.4774imageNEIF4A3NAT_cells_CD4_memory_restingGSVA_HALLMARK_HYPOXIA
chr15:50360573-50361247:+ESCAEERENSG00000011638,TMEM1590.33391.0916e-021.2150e-060.4078imageNEIF4A3;SRSF10NAT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr15:50360573-50361247:+ESCAEERENSG00000109846,CRYAB0.33451.3795e-022.4963e-100.5157imageNEIF4A3CRYABMacrophages_M0GSVA_HALLMARK_HYPOXIA
chr15:50360573-50361247:+ESCAEERENSG00000149925,ALDOA0.32071.8375e-021.7534e-060.4022imageNEIF4A3;METTL14;SRSF10NAT_cells_CD4_memory_restingGSVA_HALLMARK_MTORC1_SIGNALING
chr15:50360573-50361247:+ESCAEERENSG00000175793,SFN0.29033.1167e-021.3365e-060.4063imageNEIF4A3SFNT_cells_CD4_memory_restingGSVA_HALLMARK_P53_PATHWAY
chr15:50360573-50361247:+ESCAEERENSG00000187642,PERM10.29973.2731e-023.2851e-070.4270imageNEIF4A3NANK_cells_restingGSVA_HALLMARK_P53_PATHWAY
chr15:50363380-50370828:+GBMEERENSG00000120948,TARDBP-0.42227.4483e-042.4833e-06-0.4131imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+GBMEERENSG00000156858,PRR14-0.39891.6587e-031.8760e-06-0.4177imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_KRAS_SIGNALING_UP
chr15:50363380-50370828:+GBMEERENSG00000120742,SERP10.33871.1072e-022.8645e-060.4108imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000169221,TBC1D10B-0.33671.1707e-024.6613e-06-0.4027imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+GBMEERENSG00000128590,DNAJB90.32721.4011e-021.8745e-070.4526imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+GBMEERENSG00000214460,TPT1P60.31811.9565e-024.5460e-060.4032imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000117151,CTBS0.31582.0330e-029.2245e-070.4288imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000106034,CPED10.31542.1116e-024.0631e-060.4050imageNEIF4A3;TAF15;UPF1;FUS;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr15:50363380-50370828:+GBMEERENSG00000114850,SSR30.31352.1800e-024.5799e-070.4395imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000233846,RP11-307L3.20.31132.2077e-022.7035e-060.4118imageNNNAMacrophages_M0GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION
chr15:50363380-50370828:+GBMEERENSG00000120948,TARDBP-0.42227.4483e-042.4833e-06-0.4131imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+GBMEERENSG00000156858,PRR14-0.39891.6587e-031.8760e-06-0.4177imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_KRAS_SIGNALING_UP
chr15:50363380-50370828:+GBMEERENSG00000120742,SERP10.33871.1072e-022.8645e-060.4108imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000169221,TBC1D10B-0.33671.1707e-024.6613e-06-0.4027imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAT_cells_CD4_memory_activatedGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+GBMEERENSG00000128590,DNAJB90.32721.4011e-021.8745e-070.4526imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+GBMEERENSG00000214460,TPT1P60.31811.9565e-024.5460e-060.4032imageNNNAT_cells_gamma_deltaGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000117151,CTBS0.31582.0330e-029.2245e-070.4288imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000106034,CPED10.31542.1116e-024.0631e-060.4050imageNEIF4A3;TAF15;UPF1;FUS;U2AF2NAT_cells_CD4_memory_restingGSVA_HALLMARK_ALLOGRAFT_REJECTION
chr15:50363380-50370828:+GBMEERENSG00000114850,SSR30.31352.1800e-024.5799e-070.4395imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
chr15:50363380-50370828:+GBMEERENSG00000233846,RP11-307L3.20.31132.2077e-022.7035e-060.4118imageNNNAMacrophages_M0GSVA_HALLMARK_OXIDATIVE_PHOSPHORYLATION

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4. Enriched editing regions and immune related splicing for GABPB1-AS1


all structure

check button Enriched editing regions and immune related splicing.
* First, the associations between enriched editing regions and splicing events were tested by QTL and Pearson method (QTL: FDR<0.05 and Pearson: P<0.05).
* Second, the splicing relationships with immune were tested by three analyses: whether the splicing event locates in an immune gene (InnateDB、Immport, Immunome and Immunogenetic Related Information Source (IRIS)), whether the splicing event is associated with immune infiltration and whether the splicing event is related to immune gene sets.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of splicing events with the fraction of different immune cells and the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeSplicingTypeSplicingGeneSplicingChrSplicingPositionbetaFDRPearsonPPearsonRCorrelationPlotRBPRBPtargetsImmuneGeneImmuneFractionHallMark
chr15:50363380-50370828:+
GBMEERIRENSG00000204314.6chr632153339:32153836:32154237:32154333-0.33098.8979e-038.1733e-08-0.5293imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+
GBMEERIRENSG00000131876.12chr15101285725:101285801:101286907:101287010-0.40964.9641e-036.4176e-07-0.4377imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+
GBMEERIRENSG00000125458.2chr1775130224:75130867:75130964:75131081-0.40045.8546e-033.9753e-06-0.4070imageNEIF4A3;TAF15;UPF1;FUS;U2AF2NAMonocytesGSVA_HALLMARK_ADIPOGENESIS
chr15:50363380-50370828:+
GBMEERIRENSG00000160285.10chr2146188140:46188821:46191075:46191235-0.40896.1977e-032.6895e-08-0.4792imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000244879.4,GABPB1-AS1
GBMEAGIRENSG00000143774.12chr1228145453:228145624:228145886:228146067-0.28084.8931e-026.4215e-06-0.4068imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAGSVA_HALLMARK_ADIPOGENESIS
ENSG00000244879.4,GABPB1-AS1
GBMEAGIRENSG00000204314.6chr632153339:32153836:32154237:32154333-0.30832.4579e-022.7794e-07-0.5103imageNADAR;BCCIP;BUD13;CPSF6;CSTF2T;DDX42;EIF4A3;FAM120A;FBL;FUS;GTF2F1;HNRNPA1;HNRNPC;HNRNPK;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHSRP;LARP4B;LIN28B;LSM11;NOP56;NOP58;PCBP2;PRPF8;PTBP1;RBFOX2;RBM27;SAFB2;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF3;SRSF9;TAF15;TARDBP;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;YTHDC1;ZNF184NAMonocytesGSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+
GBMEERIRENSG00000143774.12chr1228145453:228145624:228145886:228146067-0.29822.3193e-023.2262e-06-0.4186imageNEIF4A3;TAF15;UPF1;FUS;U2AF2;YTHDC1NAGSVA_HALLMARK_ADIPOGENESIS
ENSG00000244879.4,GABPB1-AS1
GBMEAGIRENSG00000160285.10chr2146188140:46188821:46191075:46191235-0.38791.4391e-028.0906e-08-0.4644imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHSRP;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;QKI;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLBP;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARBP2;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;VIM;XRN2;YTHDC1;YWHAG;ZNF184NAMacrophages_M0GSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALING
ENSG00000244879.4,GABPB1-AS1
GBMEAGIRENSG00000131876.12chr15101285725:101285801:101286907:101287010-0.35992.9769e-025.4959e-06-0.4031imageNADAR;AIFM1;AUH;BCCIP;BUD13;CELF2;CNBP;CPSF6;CSTF2T;DDX3X;DDX42;DDX54;DGCR8;DHX9;DICER1;EIF4A3;EIF4G2;ELAVL1;EWSR1;FAM120A;FBL;FMR1;FTO;FUS;FXR1;FXR2;GNL3;GTF2F1;HNRNPA1;HNRNPA2B1;HNRNPC;HNRNPD;HNRNPK;HNRNPM;HNRNPU;HNRNPUL1;IGF2BP1;IGF2BP2;IGF2BP3;ILF3;KHDRBS1;KHDRBS2;KHDRBS3;KHSRP;LARP4B;LARP7;LIN28;LIN28A;LIN28B;LSM11;MOV10;MSI1;MSI2;NONO;NOP56;NOP58;NPM1;NUMA1;PCBP2;PRPF8;PTBP1;RANGAP1;RBFOX2;RBM10;RBM22;RBM27;RBM47;RNF219;SAFB2;SBDS;SF3A3;SF3B4;SLTM;SMNDC1;SND1;SRSF1;SRSF10;SRSF3;SRSF7;SRSF9;TAF15;TARDBP;TIA1;TIAL1;TNRC6A;TRA2A;TROVE2;U2AF1;U2AF2;UPF1;XRN2;YTHDC1;YWHAG;ZNF184NAMacrophages_M0GSVA_HALLMARK_MITOTIC_SPINDLE
chr15:50363380-50370828:+
LGGEERIRENSG00000092094.6chr1420448901:20449013:20449170:20449266-0.42326.6421e-165.8936e-20-0.4036imageNEIF4A3;TAF15;UPF1;FUS;U2AF2NAMacrophages_M1GSVA_HALLMARK_ESTROGEN_RESPONSE_LATE

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5. Enriched editing regions and immune infiltration for GABPB1-AS1


all structure

check button Associations of enriched editing regions with immune infiltration.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the fraction of different immune cells according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerTypeIDImmuneCellPRCorrelationPlot
chr15:50357390-50358295:+BLCAEERMast_cells_activated2.7350e-020.4410image
chr15:50360573-50361247:+BLCAEERDendritic_cells_resting2.0839e-020.4688image
chr15:50363380-50370828:+BLCAEERMacrophages_M14.2293e-020.1827image
chr15:50360573-50361247:+BRCAEERNK_cells_resting3.5218e-02-0.2029image
chr15:50363380-50370828:+CESCEERDendritic_cells_resting2.1346e-02-0.2655image
ENSG00000244879.4,GABPB1-AS1CESCEAGDendritic_cells_resting2.1375e-02-0.2637image
chr15:50363380-50370828:+CHOLEERDendritic_cells_resting1.1024e-03-0.6747image
ENSG00000244879.4,GABPB1-AS1CHOLEAGDendritic_cells_resting1.1836e-03-0.6716image
chr15:50363380-50370828:+COADEERNeutrophils1.2795e-020.2445image
ENSG00000244879.4,GABPB1-AS1COADEAGNeutrophils1.1327e-020.2486image
chr15:50363380-50370828:+DLBCEERMast_cells_activated4.8108e-020.4471image
chr15:50357390-50358295:+ESCAEERNK_cells_activated3.4341e-030.3660image
chr15:50360573-50361247:+ESCAEERMacrophages_M01.1477e-040.3294image
chr15:50363380-50370828:+ESCAEERMacrophages_M25.1331e-040.3124image
ENSG00000244879.4,GABPB1-AS1ESCAEAGMacrophages_M02.2286e-020.1945image
chr15:50360573-50361247:+GBMEERT_cells_CD81.9949e-030.5336image
chr15:50363380-50370828:+GBMEERMonocytes5.6220e-030.2503image
ENSG00000244879.4,GABPB1-AS1GBMEAGMonocytes5.4359e-030.2513image
chr15:50363380-50370828:+HNSCEERT_cells_follicular_helper2.0931e-020.3001image
ENSG00000244879.4,GABPB1-AS1HNSCEAGT_cells_follicular_helper2.9545e-020.2788image
chr15:50363380-50370828:+KIRCEERNeutrophils1.8580e-020.1960image
ENSG00000244879.4,GABPB1-AS1KIRCEAGNeutrophils1.8301e-020.1951image
chr15:50357390-50358295:+KIRPEERT_cells_CD4_memory_activated2.7413e-020.4243image
chr15:50363380-50370828:+KIRPEERT_cells_CD4_memory_activated2.8303e-020.1939image
ENSG00000244879.4,GABPB1-AS1KIRPEAGMacrophages_M12.2085e-020.2022image
chr15:50363380-50370828:+LAMLEEREosinophils4.8348e-02-0.1620image
ENSG00000244879.4,GABPB1-AS1LAMLEAGEosinophils1.8467e-02-0.1928image
chr15:50363380-50370828:+LGGEERMacrophages_M12.7694e-040.1664image
ENSG00000244879.4,GABPB1-AS1LGGEAGMacrophages_M18.8179e-040.1524image
chr15:50357390-50358295:+LUADEERDendritic_cells_activated3.4492e-020.3059image
chr15:50363380-50370828:+LUADEERT_cells_CD4_memory_resting3.3302e-020.1549image
ENSG00000244879.4,GABPB1-AS1LUADEAGT_cells_CD4_memory_resting4.6164e-020.1445image
chr15:50360573-50361247:+LUSCEERT_cells_regulatory_(Tregs)1.5692e-030.4894image
chr15:50363380-50370828:+LUSCEERDendritic_cells_activated4.5942e-02-0.1403image
ENSG00000244879.4,GABPB1-AS1LUSCEAGDendritic_cells_activated3.3970e-02-0.1485image
chr15:50360573-50361247:+OVEERB_cells_naive3.8874e-02-0.1437image
ENSG00000244879.4,GABPB1-AS1OVEAGNeutrophils1.1057e-030.2111image
chr15:50363380-50370828:+PAADEERT_cells_regulatory_(Tregs)2.9624e-03-0.3714image
ENSG00000244879.4,GABPB1-AS1PAADEAGT_cells_regulatory_(Tregs)1.8037e-03-0.3885image
chr15:50357390-50358295:+PRADEERT_cells_CD82.6643e-040.4067image
chr15:50363380-50370828:+PRADEERT_cells_CD4_memory_resting1.2692e-020.1541image
ENSG00000244879.4,GABPB1-AS1PRADEAGT_cells_CD4_memory_resting8.4648e-030.1620image
chr15:50363380-50370828:+READEERNK_cells_activated2.2429e-02-0.4154image
ENSG00000244879.4,GABPB1-AS1READEAGNK_cells_activated1.8859e-02-0.4262image
chr15:50363380-50370828:+SARCEERT_cells_follicular_helper1.6910e-020.2205image
ENSG00000244879.4,GABPB1-AS1SARCEAGT_cells_follicular_helper1.8790e-020.2160image
chr15:50357390-50358295:+SKCMEERT_cells_gamma_delta5.0692e-030.3695image
chr15:50360573-50361247:+SKCMEERT_cells_CD83.5983e-020.3004image
chr15:50360573-50361247:+STADEERMacrophages_M11.2293e-020.1750image
chr15:50363380-50370828:+STADEERB_cells_memory4.6200e-02-0.1411image
ENSG00000244879.4,GABPB1-AS1STADEAGMacrophages_M11.1191e-020.1632image
chr15:50363380-50370828:+TGCTEERMacrophages_M02.9888e-020.2218image
ENSG00000244879.4,GABPB1-AS1TGCTEAGMacrophages_M03.7662e-020.2125image
chr15:50360573-50361247:+THCAEERT_cells_CD83.7621e-030.4233image
chr15:50363380-50370828:+THYMEERMast_cells_resting3.4511e-020.2270image
ENSG00000244879.4,GABPB1-AS1THYMEAGMast_cells_resting2.7308e-020.2367image
chr15:50363380-50370828:+UCSEERNeutrophils1.9405e-020.4244image
ENSG00000244879.4,GABPB1-AS1UCSEAGNeutrophils1.5732e-020.4371image


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6. Enriched editing regions and immune gene sets for GABPB1-AS1


all structure

check button Correlation of enriched editing regions with epithelial-mesenchymal transition.
* First, the differences of enriched editing regions between Epi and Mes groups (defined by KS-test) were compared (P<0.05 and Informative number >=20).
* Second, the correlations between enriched editing regions and gene set score of HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly edited between Epi and Mes group.
ID_eventscancerTypeE2M_PBoxplotCorPCorRCorrelationPlot


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check button Correlations of enriched editing regions with hypoxic.
* First, there are four hypoxia scores used in the database. The first three hypoxic scores were calculated on three gene sets of Buffa, Ragnum and Winter based on one previous study (PMID: 32024819). One last hypoxia score was defined on HALLMARK_HYPOXIA by GSVA method.
* Second, the correlations enriched editing regions with the four hypoxic scores were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the EERs/EAGs significantly correlated with all four hypoxia gene set scores. For more results, please go to download page.
ID_eventscancerTypeBuffa_P Buffa_R Ragnum_P Ragnum_R Winter_P Winter_R HALLMARK_P HALLMARK_R CorrelationPlot


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check button Associations of enriched editing regions with hallmark gene sets from MSigDB.
* P<0.05 and Informative number >=20.
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the scores of 50 hallmark genesets according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerHallmarkTypeTypePRCorrelationPlot
chr15:50360573-50361247:+BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEER4.2748e-020.4168image
chr15:50363380-50370828:+BLCAGSVA_HALLMARK_UV_RESPONSE_DNEER4.7535e-030.2520image
chr15:50357390-50358295:+BLCAGSVA_HALLMARK_PROTEIN_SECRETIONEER2.0816e-02-0.4596image
ENSG00000244879.4,GABPB1-AS1BLCAGSVA_HALLMARK_UV_RESPONSE_DNEAG2.5777e-030.2663image
ENSG00000244879.4,GABPB1-AS1BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.0137e-090.2585image
chr15:50360573-50361247:+BRCAGSVA_HALLMARK_ESTROGEN_RESPONSE_EARLYEER2.4551e-020.2163image
chr15:50363380-50370828:+BRCAGSVA_HALLMARK_PROTEIN_SECRETIONEER5.2105e-090.2579image
ENSG00000244879.4,GABPB1-AS1CESCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEAG6.5132e-030.3095image
chr15:50363380-50370828:+CESCGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER8.9706e-030.2998image
ENSG00000244879.4,GABPB1-AS1COADGSVA_HALLMARK_PROTEIN_SECRETIONEAG3.4203e-020.2089image
chr15:50363380-50370828:+COADGSVA_HALLMARK_INFLAMMATORY_RESPONSEEER3.1178e-020.2125image
chr15:50363380-50370828:+ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.6782e-030.2566image
chr15:50357390-50358295:+ESCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER3.5164e-030.3652image
ENSG00000244879.4,GABPB1-AS1ESCAGSVA_HALLMARK_P53_PATHWAYEAG9.3513e-040.2786image
chr15:50360573-50361247:+ESCAGSVA_HALLMARK_HYPOXIAEER3.6572e-050.3511image
chr15:50363380-50370828:+GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.9485e-03-0.2789image
ENSG00000244879.4,GABPB1-AS1GBMGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.4834e-03-0.2726image
ENSG00000244879.4,GABPB1-AS1HNSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG4.6970e-020.2554image
ENSG00000244879.4,GABPB1-AS1KIRCGSVA_HALLMARK_ADIPOGENESISEAG5.3647e-030.2293image
chr15:50360573-50361247:+KIRCGSVA_HALLMARK_HYPOXIAEER2.1006e-020.3551image
chr15:50363380-50370828:+KIRCGSVA_HALLMARK_ADIPOGENESISEER5.6088e-030.2297image
chr15:50363380-50370828:+KIRPGSVA_HALLMARK_ANDROGEN_RESPONSEEER3.1392e-040.3135image
ENSG00000244879.4,GABPB1-AS1KIRPGSVA_HALLMARK_MITOTIC_SPINDLEEAG2.0953e-040.3221image
chr15:50357390-50358295:+KIRPGSVA_HALLMARK_COAGULATIONEER6.1657e-040.6165image
chr15:50363380-50370828:+LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER3.0408e-03-0.2412image
ENSG00000244879.4,GABPB1-AS1LAMLGSVA_HALLMARK_MYC_TARGETS_V2EAG1.5355e-03-0.2573image
chr15:50360573-50361247:+LAMLGSVA_HALLMARK_MYC_TARGETS_V2EER2.4499e-02-0.1855image
chr15:50363380-50370828:+LGGGSVA_HALLMARK_PROTEIN_SECRETIONEER4.1899e-170.3735image
ENSG00000244879.4,GABPB1-AS1LGGGSVA_HALLMARK_PROTEIN_SECRETIONEAG1.3763e-160.3677image
chr15:50357390-50358295:+LGGGSVA_HALLMARK_ADIPOGENESISEER2.9584e-070.2931image
chr15:50360573-50361247:+LGGGSVA_HALLMARK_PANCREAS_BETA_CELLSEER5.9990e-030.1671image
chr15:50363380-50370828:+LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEER1.6521e-02-0.4841image
ENSG00000244879.4,GABPB1-AS1LIHCGSVA_HALLMARK_WNT_BETA_CATENIN_SIGNALINGEAG2.7688e-02-0.4401image
chr15:50357390-50358295:+LUADGSVA_HALLMARK_COAGULATIONEER4.0779e-030.4072image
chr15:50360573-50361247:+LUADGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.3468e-040.5301image
ENSG00000244879.4,GABPB1-AS1LUADGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.2036e-030.1974image
chr15:50363380-50370828:+LUADGSVA_HALLMARK_MITOTIC_SPINDLEEER7.4599e-030.1940image
chr15:50360573-50361247:+LUSCGSVA_HALLMARK_ALLOGRAFT_REJECTIONEER1.7191e-020.3795image
ENSG00000244879.4,GABPB1-AS1LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEAG1.6964e-030.2184image
chr15:50357390-50358295:+LUSCGSVA_HALLMARK_NOTCH_SIGNALINGEER1.6932e-020.3756image
chr15:50363380-50370828:+LUSCGSVA_HALLMARK_MITOTIC_SPINDLEEER1.5316e-030.2210image
chr15:50360573-50361247:+OVGSVA_HALLMARK_XENOBIOTIC_METABOLISMEER1.2041e-030.2236image
ENSG00000244879.4,GABPB1-AS1OVGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEAG1.6755e-020.1556image
chr15:50363380-50370828:+OVGSVA_HALLMARK_MITOTIC_SPINDLEEER1.6195e-03-0.2118image
chr15:50357390-50358295:+OVGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER1.7046e-02-0.2292image
chr15:50363380-50370828:+PAADGSVA_HALLMARK_PROTEIN_SECRETIONEER4.4747e-030.3563image
ENSG00000244879.4,GABPB1-AS1PAADGSVA_HALLMARK_PROTEIN_SECRETIONEAG4.2967e-030.3578image
chr15:50363380-50370828:+PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.1505e-020.2729image
ENSG00000244879.4,GABPB1-AS1PCPGGSVA_HALLMARK_BILE_ACID_METABOLISMEAG1.2217e-020.2707image
ENSG00000244879.4,GABPB1-AS1PRADGSVA_HALLMARK_UV_RESPONSE_DNEAG1.5072e-070.3170image
chr15:50363380-50370828:+PRADGSVA_HALLMARK_UV_RESPONSE_DNEER2.4075e-070.3131image
chr15:50360573-50361247:+PRADGSVA_HALLMARK_CHOLESTEROL_HOMEOSTASISEER1.0065e-030.4512image
chr15:50363380-50370828:+READGSVA_HALLMARK_UV_RESPONSE_DNEER2.7458e-030.5274image
ENSG00000244879.4,GABPB1-AS1READGSVA_HALLMARK_UV_RESPONSE_DNEAG1.5145e-030.5534image
ENSG00000244879.4,GABPB1-AS1SARCGSVA_HALLMARK_PEROXISOMEEAG3.9731e-02-0.1896image
chr15:50363380-50370828:+SARCGSVA_HALLMARK_NOTCH_SIGNALINGEER2.3019e-02-0.2101image
chr15:50360573-50361247:+SARCGSVA_HALLMARK_ANGIOGENESISEER1.3595e-030.6521image
ENSG00000244879.4,GABPB1-AS1SKCMGSVA_HALLMARK_HEME_METABOLISMEAG5.1060e-040.2361image
chr15:50360573-50361247:+SKCMGSVA_HALLMARK_FATTY_ACID_METABOLISMEER4.2664e-020.2908image
chr15:50363380-50370828:+SKCMGSVA_HALLMARK_HEME_METABOLISMEER4.6522e-040.2394image
chr15:50357390-50358295:+SKCMGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER5.0246e-040.4500image
chr15:50363380-50370828:+STADGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER8.4735e-040.2341image
chr15:50360573-50361247:+STADGSVA_HALLMARK_P53_PATHWAYEER6.7561e-050.2753image
ENSG00000244879.4,GABPB1-AS1STADGSVA_HALLMARK_APOPTOSISEAG7.3640e-050.2525image
chr15:50360573-50361247:+TGCTGSVA_HALLMARK_BILE_ACID_METABOLISMEER1.7723e-020.4372image
ENSG00000244879.4,GABPB1-AS1TGCTGSVA_HALLMARK_MITOTIC_SPINDLEEAG6.3293e-040.3426image
chr15:50363380-50370828:+TGCTGSVA_HALLMARK_PROTEIN_SECRETIONEER6.1959e-040.3432image
chr15:50357390-50358295:+TGCTGSVA_HALLMARK_DNA_REPAIREER3.8310e-030.4828image
chr15:50360573-50361247:+THCAGSVA_HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAYEER4.4302e-030.4165image
ENSG00000244879.4,GABPB1-AS1THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEAG2.0205e-030.1899image
chr15:50363380-50370828:+THCAGSVA_HALLMARK_ANDROGEN_RESPONSEEER4.1296e-040.2174image
chr15:50363380-50370828:+THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEER6.8807e-040.3570image
ENSG00000244879.4,GABPB1-AS1THYMGSVA_HALLMARK_KRAS_SIGNALING_DNEAG8.0802e-040.3526image
chr15:50363380-50370828:+UCECGSVA_HALLMARK_TNFA_SIGNALING_VIA_NFKBEER4.7333e-020.2550image
chr15:50363380-50370828:+UCSGSVA_HALLMARK_MYC_TARGETS_V2EER4.7330e-02-0.3650image
ENSG00000244879.4,GABPB1-AS1UCSGSVA_HALLMARK_MYC_TARGETS_V2EAG4.4762e-02-0.3690image
chr15:50363380-50370828:+UVMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEER7.3136e-03-0.4651image
ENSG00000244879.4,GABPB1-AS1UVMGSVA_HALLMARK_INTERFERON_ALPHA_RESPONSEEAG7.1126e-03-0.4665image


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7. Enriched editing regions and drugs for GABPB1-AS1


all structure

check button Correlations between enriched editing regions and drug sensitivity.
* First, the drug sensitivity (IS50) was estimated on 84 drugs by pRRophetic package.
* Second, the correlations between editing enriched regions and drug sensitivity were analyzed (P<0.05 and Informative number >=20).
* EER: enriched editing region, EAG: EER-associated genes.
* Only shows the most significant correlation result of EERs/EAGs with the IS50 scores of 84 drugs according to correlation coefficient (R). For more results, please go to download page.
ID_eventscancerDrugTypePRCorrelationPlot
ENSG00000244879.4,GABPB1-AS1ACCBMS.536924EAG3.8705e-040.6438image
chr15:50363380-50370828:+ACCBMS.536924EER3.2692e-040.6498image
chr15:50360573-50361247:+BLCAAG.014699EER6.8496e-030.5367image
chr15:50363380-50370828:+BLCAAZD6482EER3.1786e-04-0.3181image
ENSG00000244879.4,GABPB1-AS1BLCAAZD6482EAG1.6728e-04-0.3292image
chr15:50357390-50358295:+BLCAJNK.Inhibitor.VIIIEER9.1521e-030.5103image
ENSG00000244879.4,GABPB1-AS1BRCAGW843682XEAG8.6567e-050.1741image
chr15:50363380-50370828:+BRCAGW843682XEER2.6702e-040.1627image
chr15:50360573-50361247:+BRCAGDC0941EER1.0585e-020.2450image
chr15:50363380-50370828:+CESCCamptothecinEER5.4103e-030.3181image
ENSG00000244879.4,GABPB1-AS1CESCCamptothecinEAG8.1943e-030.3012image
chr15:50363380-50370828:+COADBX.795EER1.0037e-02-0.2526image
ENSG00000244879.4,GABPB1-AS1COADAICAREAG1.9703e-02-0.2295image
chr15:50363380-50370828:+DLBCAxitinibEER4.9257e-020.4451image
ENSG00000244879.4,GABPB1-AS1ESCAAUY922EAG3.0813e-04-0.3027image
chr15:50363380-50370828:+ESCAGSK269962AEER3.9422e-04-0.3184image
chr15:50357390-50358295:+ESCACCT007093EER1.3473e-020.3123image
chr15:50360573-50361247:+ESCAGefitinibEER1.6362e-05-0.3668image
chr15:50360573-50361247:+GBMGW.441756EER4.1601e-02-0.3681image
ENSG00000244879.4,GABPB1-AS1GBMBAY.61.3606EAG1.6287e-030.2835image
chr15:50363380-50370828:+GBMBAY.61.3606EER2.6479e-040.3259image
ENSG00000244879.4,GABPB1-AS1HNSCKIN001.135EAG2.6614e-020.2839image
chr15:50363380-50370828:+HNSCKIN001.135EER1.3813e-020.3189image
ENSG00000244879.4,GABPB1-AS1KIRCFH535EAG3.1661e-03-0.2427image
chr15:50363380-50370828:+KIRCFH535EER2.9493e-03-0.2461image
chr15:50360573-50361247:+KIRCFTI.277EER1.2721e-02-0.3813image
chr15:50360573-50361247:+KIRPBryostatin.1EER1.2847e-02-0.4641image
chr15:50357390-50358295:+KIRPAZD7762EER1.2594e-05-0.7351image
ENSG00000244879.4,GABPB1-AS1KIRPGemcitabineEAG1.8303e-02-0.2083image
chr15:50363380-50370828:+KIRPGemcitabineEER1.6464e-02-0.2117image
chr15:50360573-50361247:+LAMLDoxorubicinEER4.2459e-050.3309image
ENSG00000244879.4,GABPB1-AS1LAMLGemcitabineEAG1.6773e-050.3446image
chr15:50363380-50370828:+LAMLBAY.61.3606EER1.1321e-030.2642image
chr15:50357390-50358295:+LGGJNK.Inhibitor.VIIIEER1.0128e-040.2244image
ENSG00000244879.4,GABPB1-AS1LGGBIRB.0796EAG7.5587e-060.2042image
chr15:50360573-50361247:+LGGABT.263EER2.1402e-030.1864image
chr15:50363380-50370828:+LGGBIRB.0796EER3.0192e-060.2128image
ENSG00000244879.4,GABPB1-AS1LIHCBryostatin.1EAG1.1672e-03-0.6114image
chr15:50363380-50370828:+LIHCAZD7762EER2.7338e-04-0.6778image
ENSG00000244879.4,GABPB1-AS1LUADBMS.536924EAG3.1205e-030.2134image
chr15:50363380-50370828:+LUADBMS.536924EER5.8279e-030.2004image
chr15:50357390-50358295:+LUADDocetaxelEER2.4109e-02-0.3252image
chr15:50360573-50361247:+LUADAZ628EER1.7244e-05-0.6437image
chr15:50360573-50361247:+LUSCAZD8055EER1.1302e-03-0.5020image
chr15:50357390-50358295:+LUSCMidostaurinEER1.4554e-03-0.4866image
ENSG00000244879.4,GABPB1-AS1LUSCABT.263EAG1.7395e-02-0.1664image
chr15:50363380-50370828:+LUSCABT.263EER2.0530e-02-0.1625image
ENSG00000244879.4,GABPB1-AS1MESOKIN001.135EAG3.9078e-02-0.3361image
chr15:50363380-50370828:+MESOKIN001.135EER3.9440e-02-0.3356image
ENSG00000244879.4,GABPB1-AS1OVMG.132EAG1.2689e-03-0.2090image
chr15:50363380-50370828:+OVBMS.509744EER3.3622e-07-0.3366image
chr15:50357390-50358295:+OVABT.888EER8.7301e-040.3157image
chr15:50360573-50361247:+OVBortezomibEER2.2679e-04-0.2536image
chr15:50363380-50370828:+PAADIPA.3EER1.2425e-020.3236image
ENSG00000244879.4,GABPB1-AS1PAADIPA.3EAG9.7867e-030.3338image
ENSG00000244879.4,GABPB1-AS1PCPGAZD.2281EAG6.6241e-030.2924image
chr15:50363380-50370828:+PCPGAZD.2281EER6.0983e-030.2952image
ENSG00000244879.4,GABPB1-AS1PRADGW.441756EAG1.2510e-060.2937image
chr15:50360573-50361247:+PRADBleomycinEER5.0786e-030.3903image
chr15:50363380-50370828:+PRADMetforminEER1.5038e-060.2926image
ENSG00000244879.4,GABPB1-AS1READAZD6482EAG6.1535e-04-0.5891image
chr15:50363380-50370828:+READBexaroteneEER5.3937e-04-0.5940image
chr15:50363380-50370828:+SARCBosutinibEER4.8899e-040.3174image
ENSG00000244879.4,GABPB1-AS1SARCBosutinibEAG4.7531e-040.3167image
chr15:50360573-50361247:+SARCGDC.0449EER2.2381e-02-0.4954image
ENSG00000244879.4,GABPB1-AS1SKCMElesclomolEAG2.8165e-030.2037image
chr15:50360573-50361247:+SKCMBosutinibEER8.4824e-030.3720image
chr15:50363380-50370828:+SKCMDMOGEER2.0738e-03-0.2114image
chr15:50357390-50358295:+SKCMBryostatin.1EER1.4506e-020.3251image
chr15:50360573-50361247:+STADAMG.706EER1.7982e-040.2594image
chr15:50363380-50370828:+STADCisplatinEER1.5528e-02-0.1709image
ENSG00000244879.4,GABPB1-AS1STADAMG.706EAG9.7870e-030.1661image
chr15:50363380-50370828:+TGCTCEP.701EER4.5424e-020.2047image
chr15:50360573-50361247:+TGCTAP.24534EER3.2139e-02-0.3988image
chr15:50357390-50358295:+TGCTElesclomolEER2.4045e-02-0.3863image
ENSG00000244879.4,GABPB1-AS1TGCTCEP.701EAG3.6471e-020.2138image
ENSG00000244879.4,GABPB1-AS1THCAGW843682XEAG6.4827e-040.2094image
chr15:50360573-50361247:+THCAAP.24534EER4.2599e-020.3036image
chr15:50363380-50370828:+THCAGW843682XEER1.7696e-030.1930image
chr15:50363380-50370828:+THYMAZD.0530EER1.5226e-03-0.3349image
ENSG00000244879.4,GABPB1-AS1THYMAZD.0530EAG1.5872e-03-0.3337image
ENSG00000244879.4,GABPB1-AS1UCECAZD7762EAG1.6612e-02-0.2961image
chr15:50363380-50370828:+UCECErlotinibEER7.0016e-03-0.3419image
chr15:50363380-50370828:+UCSLapatinibEER2.1205e-03-0.5389image
ENSG00000244879.4,GABPB1-AS1UCSLapatinibEAG2.0878e-03-0.5396image
chr15:50363380-50370828:+UVMAxitinibEER6.5621e-03-0.4706image
ENSG00000244879.4,GABPB1-AS1UVMAxitinibEAG8.4830e-03-0.4574image


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check button EAGs targeted by drugs from DrugBank database.
* EAG: EER-associated genes.
EERENSTUniprotIDDrugBankIDDrugDrugType